CD83 抗体 (N-Term)
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Quick Overview for CD83 抗体 (N-Term) (ABIN7879583)
抗原
See all CD83 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- N-Term
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原理
- CD83 Antibody (azide and preservative free)
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纯化方法
- Protein G affinity
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免疫原
- Prokaryotic recombinant protein corresponding to 124 amino acids of the external N-terminus of the CD83 molecule was used as the immunogen for the CD83 antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the CD83 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the CD83 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- CD83
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别名
- CD83
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背景
- CD83 is a heavily glycosylated membrane protein of the immunoglobulin (Ig) superfamily that is expressed in mature Dendritic cells, Langerhans cells and interdigitating reticulum cells within lymphoid tissues. Structurally, CD83 resembles other Ig superfamily members, which have an extracellular V-type Ig-like domain, a single transmembrane domain and a 40 residue cytoplasmic tail. CD83 expression is used as a marker for mature, antigen presenting Dendritic cells that are capable of generating tumor-specific T cell immunity, a phenotype with implications as an anti-cancer vaccine. CD83-IgG1(Fc) chimera studies indicate that CD83 is a sialic acid-binding, Ig-like Lectin (Siglec) adhesion molecule that is involved in cell adhesion/signaling by hosting Dendritic cell interactions with monocytes and CD8+ T cells.
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UniProt
- Q01151
抗原
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