ALDOC 抗体 (N-Term)
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Quick Overview for ALDOC 抗体 (N-Term) (ABIN7879558)
抗原
See all ALDOC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- ALDOC Antibody / Aldolase C
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human Aldolase C/ALDOC was used as the immunogen for the ALDOC antibody.
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亚型
- IgG
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anti-Aldolase C, Fructose-Bisphosphate (ALDOC) (N-Term) antibody
ALDOC 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Aldolase C, Fructose-Bisphosphate (ALDOC) (AA 190-354) antibodyALDOC 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Aldolase C, Fructose-Bisphosphate (ALDOC) (AA 1-170) antibodyALDOC 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Aldolase C, Fructose-Bisphosphate (ALDOC) antibodyALDOC 适用: 人, 小鼠, 大鼠 WB 宿主: 小鼠 Monoclonal 859CT9-5-3 unconjugated
anti-Aldolase C, Fructose-Bisphosphate (ALDOC) (AA 1-364) antibodyALDOC 适用: 人 WB, ELISA, IF, ICC 宿主: 小鼠 Monoclonal AT2E11 unconjugated
anti-Aldolase C, Fructose-Bisphosphate (ALDOC) antibodyALDOC 适用: 人 WB, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Aldolase C, Fructose-Bisphosphate (ALDOC) (AA 300-333), (C-Term) antibodyALDOC 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB14664 unconjugated
anti-Aldolase C, Fructose-Bisphosphate (ALDOC) (AA 300-333) antibodyALDOC 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Aldolase C, Fructose-Bisphosphate (ALDOC) (C-Term) antibodyALDOC 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Aldolase C, Fructose-Bisphosphate (ALDOC) (N-Term) antibodyALDOC 适用: 人, 小鼠, 大鼠, Cow, Pig, 犬, 兔, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the ALDOC antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the ALDOC antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- ALDOC (Aldolase C, Fructose-Bisphosphate (ALDOC))
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别名
- ALDOC
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背景
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ALDOC antibody detects Aldolase C, a glycolytic enzyme involved in the reversible cleavage of fructose-1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate. Encoded by the ALDOC gene on chromosome 17q11.2, this protein is one of three aldolase isoenzymes (A, B, and C) expressed in a tissue-specific manner. Aldolase C is predominantly found in the brain and other neural tissues, where it supports both glycolytic energy metabolism and neuronal development.
Structurally, Aldolase C functions as a homotetramer with catalytic lysine residues that form Schiff bases with its substrate. It shares high sequence identity with Aldolase A (muscle type) and B (liver type) but exhibits unique kinetic properties suited for neuronal metabolism. In neurons and glial cells, Aldolase C contributes to glucose utilization, energy coupling, and maintenance of synaptic function. It also interacts with cytoskeletal proteins, suggesting roles beyond metabolism, including regulation of actin organization and cell morphology.
The ALDOC antibody is widely used in neuroscience, metabolism, and cell biology research to study glycolytic regulation and neural differentiation. Western blot analysis identifies a 39 kilodalton band corresponding to Aldolase C, while immunohistochemistry reveals strong cytoplasmic staining in Purkinje cells and astrocytes. This antibody supports investigation of metabolic compartmentalization and energy flux in the central nervous system.
Altered expression of Aldolase C has been observed in neurodegenerative diseases and gliomas, where metabolic reprogramming contributes to pathogenesis. Beyond the brain, ALDOC expression in epithelial and endocrine tissues suggests additional roles in energy balance and biosynthesis. The ALDOC antibody provides a reliable reagent for analyzing glycolytic enzyme distribution and function. NSJ Bioreagents offers this antibody validated for its applications, ensuring high specificity and reproducibility for metabolic and neurobiological studies. -
UniProt
- P09972
抗原
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