PAX7 抗体 (Middle Region)
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北京 101111
Quick Overview for PAX7 抗体 (Middle Region) (ABIN7879536)
抗原
See all PAX7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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原理
- PAX7 Antibody / Paired box protein 7
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human PAX7 was used as the immunogen for the PAX7 antibody.
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亚型
- IgG
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anti-Paired Box 7 (PAX7) (AA 411-520) antibody
PAX7 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3C9 unconjugated
anti-Paired Box 7 (PAX7) (N-Term) antibodyPAX7 适用: 人, 小鼠, 大鼠, 斑马鱼, 犬, 豚鼠, Cow, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Paired Box 7 (PAX7) (Middle Region) antibodyPAX7 适用: 人, 小鼠, 大鼠, 斑马鱼, 犬, 豚鼠, Cow, 兔, 山羊 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Paired Box 7 (PAX7) (AA 411-520) antibodyPAX7 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1E12 unconjugated
anti-Paired Box 7 (PAX7) (AA 411-520) antibodyPAX7 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1G11 unconjugated
anti-Paired Box 7 (PAX7) (AA 167-216) antibodyPAX7 适用: 人, 小鼠, 大鼠, 小鸡, 犬, 豚鼠, Cow, 兔, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Paired Box 7 (PAX7) (AA 410-460) antibodyPAX7 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Paired Box 7 (PAX7) (AA 410-437), (C-Term) antibodyPAX7 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB28560 unconjugated
anti-Paired Box 7 (PAX7) (AA 411-521) antibodyPAX7 适用: 人, 小鼠 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1E12 unconjugated
anti-Paired Box 7 (PAX7) (AA 301-505) antibodyPAX7 适用: 人, 小鼠, 大鼠, 斑马鱼, 小鸡 WB, FACS, IF 宿主: 小鼠 Monoclonal PAX7-497 unconjugated
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应用备注
- Optimal dilution of the PAX7 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PAX7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PAX7 (Paired Box 7 (PAX7))
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别名
- PAX7
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背景
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PAX7 antibody detects Paired box protein 7, a transcription factor critical for myogenesis, neural crest formation, and satellite cell maintenance. PAX7 belongs to the paired box family of transcriptional regulators that control early developmental programs through DNA binding and transcriptional activation. The PAX7 antibody is widely used in developmental and muscle biology to study stem cell regulation and tissue regeneration.
PAX7 is encoded by the PAX7 gene located on human chromosome 1p36.13. The protein contains a paired DNA-binding domain, a homeodomain, and a C-terminal transactivation domain. During embryonic development, PAX7 is expressed in neural crest cells and the myogenic progenitor population of the somites. In adults, it marks quiescent muscle satellite cells responsible for postnatal muscle repair and regeneration.
The PAX7 antibody identifies a 55 kilodalton nuclear protein by western blot and demonstrates strong nuclear staining in satellite cells and developing muscle fibers. Loss of PAX7 disrupts myogenic lineage specification, resulting in impaired muscle growth. Functionally, PAX7 activates myogenic regulatory factors such as MYOD and MYF5 and promotes self-renewal of satellite cells through repression of differentiation pathways.
Beyond muscle tissue, PAX7 contributes to neurogenesis, pituitary development, and craniofacial patterning. Dysregulation of PAX7 is linked to rhabdomyosarcoma, where gene fusions with FOXO1 create oncogenic transcriptional drivers. NSJ Bioreagents provides a validated PAX7 antibody, enabling precise detection of muscle progenitors and developmental regulators. -
UniProt
- P23759
抗原
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