CLTB 抗体 (Middle Region)
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北京 101111
Quick Overview for CLTB 抗体 (Middle Region) (ABIN7879511)
抗原
See all CLTB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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原理
- CLTB Antibody / Clathrin light chain B
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human CLTB was used as the immunogen for the CLTB antibody.
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亚型
- IgG
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anti-Clathrin, Light Chain B (CLTB) (AA 1-211) antibody
CLTB 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4B12-1E3 unconjugated
anti-Clathrin, Light Chain B (CLTB) (AA 1-211) antibodyCLTB 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Clathrin, Light Chain B (CLTB) antibodyCLTB 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Clathrin, Light Chain B (CLTB) antibodyCLTB 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Clathrin, Light Chain B (CLTB) (AA 1-211) antibodyCLTB 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Clathrin, Light Chain B (CLTB) (AA 1-211) antibodyCLTB 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Clathrin, Light Chain B (CLTB) (AA 1-211) antibodyCLTB 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Clathrin, Light Chain B (CLTB) (C-Term) antibodyCLTB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Clathrin, Light Chain B (CLTB) (C-Term) antibodyCLTB 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Clathrin, Light Chain B (CLTB) antibodyCLTB 适用: 人 WB 宿主: 兔 Polyclonal RB23151 unconjugated
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应用备注
- Optimal dilution of the CLTB antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the CLTB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- CLTB (Clathrin, Light Chain B (CLTB))
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别名
- CLTB
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背景
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CLTB antibody detects Clathrin light chain B, a component of clathrin-coated vesicles essential for endocytosis and intracellular trafficking. The UniProt recommended name is Clathrin light chain B (CLTB). This cytoplasmic protein associates with clathrin heavy chains to form triskelion structures that assemble into coated pits and vesicles mediating membrane transport.
Functionally, CLTB antibody identifies a 248-amino-acid protein that stabilizes clathrin triskelia and regulates their disassembly during vesicle recycling. CLTB modulates the curvature and dynamics of the clathrin coat, influencing receptor-mediated endocytosis, synaptic vesicle turnover, and Golgi trafficking. It acts in concert with accessory proteins such as Hsc70 and auxilin during clathrin uncoating.
The CLTB gene is located on chromosome 5q35.3 and is ubiquitously expressed, with high levels in neuronal and endocrine tissues. CLTB's co-expression with Clathrin light chain A (CLTA) allows tissue-specific modulation of vesicular transport efficiency and kinetics. It contributes to receptor internalization and synaptic function.
Pathologically, altered CLTB expression has been linked to neurodegenerative and metabolic disorders. Variants affecting clathrin assembly disrupt synaptic vesicle trafficking, leading to impaired neurotransmission. Research using CLTB antibody supports studies in endocytosis, membrane dynamics, and intracellular transport mechanisms.
CLTB antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect clathrin complex proteins. NSJ Bioreagents provides CLTB antibody reagents optimized for cell biology, neuroscience, and membrane trafficking studies.
Structurally, Clathrin light chain B binds to the proximal leg of clathrin heavy chains through its N-terminal domain and regulates triskelion assembly via its flexible C-terminal tail. This antibody enables analysis of CLTB's structural and regulatory roles in clathrin-mediated vesicle formation. -
UniProt
- P09497
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途径
- Synaptic Membrane
抗原
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