Cathepsin F 抗体 (Middle Region)
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Quick Overview for Cathepsin F 抗体 (Middle Region) (ABIN7879509)
抗原
See all Cathepsin F (CTSF) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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原理
- CTSF Antibody / Cathepsin F
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human Cathepsin F/CTSF was used as the immunogen for the CTSF antibody.
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亚型
- IgG
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anti-Cathepsin F (CTSF) (AA 249-462) antibody
CTSF 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Cathepsin F (CTSF) (AA 261-290) antibodyCTSF 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB19248 unconjugated
anti-Cathepsin F (CTSF) (AA 270-484) antibodyCTSF 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cathepsin F (CTSF) antibodyCTSF 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Cathepsin F (CTSF) (AA 1-484) antibodyCTSF 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Cathepsin F (CTSF) (C-Term) antibodyVerified CTSF 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Cathepsin F (CTSF) antibody (Biotin)CTSF 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal Biotin
anti-Cathepsin F (CTSF) antibody (FITC)CTSF 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal FITC
anti-Cathepsin F (CTSF) antibody (HRP)CTSF 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal HRP
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应用备注
- Optimal dilution of the CTSF antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the CTSF antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Cathepsin F (CTSF)
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别名
- CTSF
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背景
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CTSF antibody detects Cathepsin F, a lysosomal cysteine protease that mediates protein degradation and turnover in endosomal and lysosomal compartments. The UniProt recommended name is Cathepsin F (CTSF). This protease belongs to the papain-like family of cysteine cathepsins involved in cellular protein recycling and immune antigen processing.
Functionally, CTSF antibody identifies a 484-amino-acid preproenzyme that undergoes proteolytic maturation into active heavy and light chains. Cathepsin F participates in degradation of intracellular and endocytosed proteins, contributing to antigen presentation via MHC class II molecules. It also influences apoptosis, tissue remodeling, and neurodegenerative processes through regulated proteolysis.
The CTSF gene is located on chromosome 11q13.1 and is expressed in brain, liver, spleen, and macrophages. Cathepsin F maintains lysosomal proteolytic balance and participates in innate immune defense through controlled protein breakdown and turnover.
Pathologically, CTSF mutations cause Kufs disease type B, an adult-onset neuronal ceroid lipofuscinosis characterized by progressive neurodegeneration. Dysregulated Cathepsin F expression has also been associated with cancer progression and inflammatory diseases. Research using CTSF antibody supports studies in lysosomal biology, protease regulation, and neurodegenerative mechanisms.
CTSF antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect lysosomal proteases. NSJ Bioreagents provides CTSF antibody reagents optimized for proteolysis, neurobiology, and cellular homeostasis research.
Structurally, Cathepsin F features an N-terminal cystatin-like domain and a papain-like catalytic domain containing the conserved cysteine-histidine-asparagine catalytic triad. This antibody enables examination of CTSF's role in lysosomal degradation and neuronal maintenance. -
UniProt
- Q9UBX1
抗原
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