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TYR 抗体 (full length)

This 小鼠 单克隆 antibody specifically detects TYR in IHC (p). It exhibits reactivity toward 人.
产品编号 ABIN7879271
发货至: 中国
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Quick Overview for TYR 抗体 (full length) (ABIN7879271)

抗原

See all TYR 抗体
TYR (Tyrosinase (TYR))

适用

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宿主

  • 88
  • 56
小鼠

克隆类型

  • 85
  • 60
单克隆

标记

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This TYR antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

TYR-3826
  • 抗原表位

    • 15
    • 7
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    • 2
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    • 2
    • 1
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    • 1
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    full length

    原理

    Tyrosinase Antibody

    纯化方法

    Protein A/G affinity

    免疫原

    Recombinant full-length human Tyrosinase protein was used as the immunogen for the Tyrosinase antibody.

    亚型

    IgG2b, kappa
  • 应用备注

    Optimal dilution of the Tyrosinase antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the Tyrosinase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    TYR (Tyrosinase (TYR))

    别名

    Tyrosinase

    背景

    Recognizes a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway, the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants.This MAb is a useful marker for melanocytes and melanomas.

    UniProt

    P14679
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