TARBP2 抗体 (full length)
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Quick Overview for TARBP2 抗体 (full length) (ABIN7879127)
抗原
See all TARBP2 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- full length
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原理
- TARBP2 Antibody (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- Recombinant full-length human TARBP2 protein was used as the immunogen for the TARBP2 antibody.
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亚型
- IgG2a
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应用备注
- Optimal dilution of the TARBP2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the TARBP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- TARBP2 (TAR (HIV-1) RNA Binding Protein 2 (TARBP2))
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别名
- TARBP2
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背景
- TRBP2, also known as TARBP2 (trans-activation-responsive (HIV-1) RNA binding protein 2), TRBP1 or TRBP, is a nuclear protein that contains three DRBM (double-stranded RNA-binding) domains. TRBP binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. The third DRBM motif in the C-terminus of human TRBP2 can interact with and inhibit PKR activity, thereby increasing HIV-1 long terminal repeat (LTR) expression. In addition, TRBP2 functions as a component of a Dicer-containing complex and associates with the catalytic subunit of the RNA-induced silencing complex (RISC), namely eIF2C2. TRBP2 is essential for Dicer stability and the proper assembly of RISC. This suggests that TRBP2, in association with Dicer, plays an important role in the processing of miRNAs (microRNAs).
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UniProt
- Q15633
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途径
- Regulatory RNA Pathways, Ribonucleoprotein Complex Subunit Organization
抗原
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