TAL1 抗体 (full length)
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北京 101111
Quick Overview for TAL1 抗体 (full length) (ABIN7879109)
抗原
See all TAL1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- full length
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原理
- TAL1 Antibody / T-cell acute lymphocytic leukemia protein 1 (azide and preservative free)
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纯化方法
- Protein G affinity chromatography
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免疫原
- A recombinant human full-length TAL1 protein was used as the immunogen for the TAL1 antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the TAL1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the TAL1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))
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别名
- TAL1
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背景
- Activation of TAL1 characterizes up to 60 % of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIHLH transcription factors.
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UniProt
- P17542
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途径
- Stem Cell Maintenance
抗原
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