Peroxiredoxin 4 抗体 (full length)
Our Local Distributor
北京 101111
Quick Overview for Peroxiredoxin 4 抗体 (full length) (ABIN7878790)
抗原
See all Peroxiredoxin 4 (PRDX4) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- full length
-
原理
- Peroxiredoxin 4 Antibody / PRDX4
-
纯化方法
- Protein A/G affinity
-
免疫原
- Recombinant full-length human PRDX4 protein was used as the immunogen for the Peroxiredoxin 4 antibody.
-
亚型
- IgG2b, kappa
-
-
-
-
应用备注
- Optimal dilution of the Peroxiredoxin 4 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.2 mg/mL
-
缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Aliquot the Peroxiredoxin 4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
-
-
- Peroxiredoxin 4 (PRDX4)
-
别名
- Peroxiredoxin 4
-
背景
- The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX IV gene is expressed in many tissues. It exists as a precursor protein, which is only detected in testis, and aprocessed secreted form. PRX IV is highly expressed in lung cancer and is necessary for the promotion of lung cancer in vitro. Studies have demonstrated that PRX IV positive expression is significantly correlated with recurrences and shorter disease-free survival in patients with early-stage lung squamous cell carcinoma, and therefore can be used as a prognostic marker in lung squamous cell carcinoma.
-
UniProt
- Q13162
抗原
-