OTX2 抗体 (full length)
Our Local Distributor
北京 101111
Quick Overview for OTX2 抗体 (full length) (ABIN7878767)
抗原
See all OTX2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- full length
-
原理
- OTX2 Antibody / Orthodenticle homolog 2
-
纯化方法
- Protein A/G affinity
-
免疫原
- Recombinant human full-length OTX2 protein was used as the immunogen for the OTX2 antibody.
-
亚型
- IgG1
-
-
-
-
应用备注
- Optimal dilution of the OTX2 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.2 mg/mL
-
缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot the OTX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
-
-
- OTX2 (Orthodenticle Homeobox 2 (OTX2))
-
别名
- OTX2
-
背景
- Transcription factors OTX1 and OTX2, two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q22.3, respectively.
-
UniProt
- P32243
-
途径
- Dopaminergic Neurogenesis
抗原
-