MBNL3 抗体 (full length)
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北京 101111
Quick Overview for MBNL3 抗体 (full length) (ABIN7878659)
抗原
See all MBNL3 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- full length
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原理
- MBNL3 Antibody (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- Recombinant full-length human MBNL3 protein was used as the immunogen for the MBNL3 antibody.
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亚型
- IgG2b
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anti-Muscleblind-Like Splicing Regulator 3 (MBNL3) (AA 1-258) antibody
MBNL3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Muscleblind-Like Splicing Regulator 3 (MBNL3) (AA 116-211) antibodyMBNL3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Muscleblind-Like Splicing Regulator 3 (MBNL3) antibodyMBNL3 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Muscleblind-Like Splicing Regulator 3 (MBNL3) antibodyMBNL3 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Muscleblind-Like Splicing Regulator 3 (MBNL3) (AA 251-280) antibodyMBNL3 适用: 人 WB 宿主: 兔 Polyclonal RB33051 unconjugated
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应用备注
- Optimal dilution of the MBNL3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the MBNL3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- MBNL3 (Muscleblind-Like Splicing Regulator 3 (MBNL3))
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别名
- MBNL3
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背景
- Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Several protein complexes are involved in proper mRNA splicing and transport. The muscleblind proteins, MBNL1, MBNL2 and MBNL3, promote inclusion or exclusion of specific exons on different pre-mRNAs by antagonizing the activity of CUG-BP and ETR-3-like factors bound to distinct intronic sites. MBNL1 and 2, which associate with expanded CUG repeats in vitro, localize to the nuclear foci in both DM1 and DM2 (myotonic dystrophy types 1 and 2), suggesting that the nuclear accumulation of mutant RNA is pathogenic in DM1, therefore implicating MBNL1 and 2 in the pathogenesis of both disorders. MBNL3, a 354 amino acid protein, inhibits expression of muscle differentiation, opposite to the function of MBNL1, which functions as a promoter of muscle differentiation. MBNL3 shows strong expression in placenta.
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UniProt
- Q9NUK0
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途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
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