MTF1 抗体 (full length)
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Quick Overview for MTF1 抗体 (full length) (ABIN7878611)
抗原
See all MTF1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- full length
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原理
- MTF1 Antibody / Metal regulatory transcription factor 1 (azide and preservative free)
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纯化方法
- Protein G affinity chromatography
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免疫原
- A recombinant full-length human protein was used as the immunogen for the MTF1 antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the MTF1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the MTF1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))
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别名
- MTF1
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背景
- The metal-responsive element (MRE)-binding transcription factor (MTF-1) stimulates the expression of metallothioneins in response to the exposure of cells to heavy metals. MTF-1 contains six zinc fingers in the DNA binding domain. The phosphorylation of MTF-1 in response to metal exposure appears to play a significant role in the ability of MTF-1 to activate metallothionein transcription. In addition to its role in metallothionein activation, MTF-1 is involved in a post-transcription regulatory complex for ribosomal protein S25. MTF-1, La and p53 inhibit the nuclear export of S25 mRNA in response to nutrient depravation. Furthermore, MTF-1 acts as a chromatin insulator on integrated transgenes in cultured cells to insulate active loci against chromatin silencing.
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UniProt
- Q14872
抗原
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