MED7 抗体 (full length)
Our Local Distributor
北京 101111
Quick Overview for MED7 抗体 (full length) (ABIN7878596)
抗原
See all MED7 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
-
-
抗原表位
- full length
-
原理
- MED7 Antibody (azide and preservative free)
-
纯化方法
- Protein A/G affinity
-
免疫原
- Recombinant full-length human protein was used as the immunogen for the MED7 antibody.
-
亚型
- IgG2b
-
-
-
-
应用备注
- Optimal dilution of the MED7 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
-
储存液
- Azide free
-
储存条件
- -20 °C
-
储存方法
- Aliquot the MED7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
-
-
- MED7 (Mediator Complex Subunit 7 (MED7))
-
别名
- MED7
-
背景
- MED7 (Mediator of RNA polymerase II transcription subunit 7), also known as HKQ, QK, QK3 or quaking, is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, MED7 functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5. Additionally, MED7 regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. MED7 may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases MED7 mRNA-binding affinity. Defects or deletions in the gene encoding MED7 are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of MED7 exist due to alternative splicing events.
-
UniProt
- O43513
-
途径
- Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha
抗原
-