MLX 抗体 (full length)
Our Local Distributor
北京 101111
Quick Overview for MLX 抗体 (full length) (ABIN7878588)
抗原
See all MLX 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
-
-
抗原表位
- full length
-
原理
- MLX Antibody / Max-like protein X (azide and preservative free)
-
纯化方法
- Protein A/G affinity
-
免疫原
- Recombinant full-length human MLX protein was used as the immunogen for the MLX antibody.
-
亚型
- IgG2b
-
-
-
-
应用备注
- Optimal dilution of the MLX antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
-
储存液
- Azide free
-
储存条件
- -20 °C
-
储存方法
- Aliquot the MLX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
-
-
- MLX (MAX-Like Protein X (MLX))
-
别名
- MLX
-
背景
- Max is a nuclear localized bHLH-Zip protein that forms homodimers or heterodimers with Myc family members, including Myc, Mad1, Mad3, Mad4, Mxi1 and Mnt (or Rox). These dimers bind to the E-box sequence CACGTG in order to regulate cell growth, proliferation and apoptosis. Mlx (Max-like protein X) is a bHLH-Zip protein that is structurally and functionally related to Max. Like Max, Mlx is broadly expressed in many tissues and has a long half-life. Mlx also forms homodimers or heterodimers with members of the Myc family, specifically Mad1, Mad4 and Rox, and members of the Mondo family, to repress or activate transcription from CACGTG E-boxes. MondoA forms weak homodimers and preferentially forms heterodimers with Mlx. The MondoA/Mlx complex is primarily localized to the cytoplasm, but will translocate to the nucleus in response to leptomycin B. Mlx can also dimerize with WBSCR14, a protein involved in Williams-Beuren syndrome (WBS), to repress E-box transcription, which provides further evidence that Mlx is a critical element in a transcription factor network.
-
UniProt
- Q9UH92
抗原
-