MXI1 抗体 (full length)
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Quick Overview for MXI1 抗体 (full length) (ABIN7878586)
抗原
See all MXI1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- full length
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原理
- MXI1 Antibody / Max-interacting protein 1 / BHLHC11 (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- Recombinant full-length human MXI1 protein was used as the immunogen for the MXI1 antibody.
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亚型
- IgG2b
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应用备注
- Optimal dilution of the MXI1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the MXI1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- MXI1 (MAX Interactor 1 (MXI1))
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别名
- MXI1
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背景
- It is now well established that Myc regulation of cell proliferation and differentiation involves a family of related transcription factors. One such factor, Max, is an obligate heterodimeric partner for Myc and can also form heterodimers with at least four related proteins designated Mad 1, Mxi1 (also designated Mad 2), Mad 3 and Mad 4. Like Mad 1 and Mxi1, association of Mad 3 and Mad 4 with Max results in transcriptional repression. Both Myc and the Mad proteins have short half-lives and their synthesis is tightly regulated, while Max expression is constitutive and relatively stable. Two related mammalian cDNAs have been identified and shown to encode Mad- binding proteins. Both possess sequence homology with the yeast transcription repressor Sin3 including four conserved paired amphipathic helix (PAH) domains. mSin3A and mSin3B specifically interact with the Mad proteins via their second paired amphipathic helix domain (PAH2). It has been suggested that Mad-Max heterodimers repress transcription by tethering mSin3 to DNA as corepressors.
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UniProt
- P50539
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途径
- Maintenance of Protein Location
抗原
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