KDM5C 抗体 (full length)
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北京 101111
Quick Overview for KDM5C 抗体 (full length) (ABIN7878544)
抗原
See all KDM5C 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- full length
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原理
- JARID1C Antibody / KDM5C / SMCX (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- Recombinant full-length human protein was used as the immunogen for the JARID1C antibody.
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亚型
- IgG2c
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anti-Lysine (K)-Specific Demethylase 5C (KDM5C) antibody
KDM5C 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 5C (KDM5C) (AA 275-325) antibodyKDM5C 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 5C (KDM5C) (AA 45-324) antibodyKDM5C 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 5C (KDM5C) (AA 10-261) antibodyKDM5C 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 5C (KDM5C) (C-Term) antibodyKDM5C 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 5C (KDM5C) (C-Term) antibodyKDM5C 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 5C (KDM5C) antibodyKDM5C 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the JARID1C antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the JARID1C antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))
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别名
- JARID1C
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背景
- SmcX, also known as JARID1C (jumonji, AT rich interactive domain 1C), MRXJ, KDM5C or XE169, is a nuclear protein that contains one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers and belongs to the JARID1 histone demethylase family. Expressed ubiquitously with highest expression in brain and skeletal muscle, SmcX functions as a histone demethylase that removes methyl groups from lysine residues on Histone H3, thereby playing a role in the histone code, as well as transcriptional regulation and chromatin remodeling. SmcX binds iron and a-ketoglutarate as cofactors and can recruit histone deacetylases to neuron silencer elements, thus repressing the transcription of neuronal genes. Defects in the gene encoding SmcX are associated with X-linked mental retardation (XLMR), a condition characterized by cognitive impairment and a low IQ. Multiple isoforms of SmcX are expressed due to alternative splicing events.
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UniProt
- P41229
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途径
- Warburg Effect
抗原
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