Recombinant Desmocollin 2+3 (full length) 抗体
The 兔 单克隆 anti-Desmocollin 2+3 antibody (Clone DSC2-9165R) (ABIN7878136) specifically detects Desmocollin 2+3 in IHC (p).
The antibody is reactive with 人 samples.
产品编号 ABIN7878136
发货至:
中国
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Contact Info
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中国
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北京 101111
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Quick Overview for Recombinant Desmocollin 2+3 (full length) 抗体 (ABIN7878136)
抗原
Desmocollin 2+3
抗体类型
Recombinant Antibody
适用
人
宿主
兔
克隆类型
单克隆
标记
非结合性
应用范围
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
质量等级
Carrier-free
克隆位点
DSC2-9165R
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抗原表位
- full length
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原理
- Recombinant Desmocollin-2/3 Antibody (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- Recombinant full-length human DSC2 protein was used as the immunogen for the recombinant Desmocollin-2/3 antibody.
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亚型
- IgG
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anti-Desmocollin 2+3 (Extracellular) antibody
Carrier-free 适用: 人, 小鼠, 大鼠 IF, WB, FACS, IHC (p) 宿主: 小鼠 Monoclonal 7G6 unconjugated
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应用备注
- Optimal dilution of the recombinant Desmocollin-2/3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the recombinant Desmocollin-2/3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Desmocollin 2+3
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别名
- Desmocollin-2/3
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背景
- Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. The desmosome is subdivided into two regions. The plaque region lies adjacent to the plasma, and is believed to contain molecules that attach the intermediate filament cytoskeleton to the desmosome. The core region is composed of transmembrane glycoproteins that are thought to mediate cell-cell adhesion. Desmogleins and desmocollins are the main desmosomal transmembrane proteins. These desmosomal glycoproteins belong to the members of the cadherin family of adhesion molecules. Three different isoforms of both desmogleins and desmocollins have been identified, named as desmoglein 1-3 and desmocollins. Desmosomal cadherins showed differentiation-specific expression in the human epidermis, although the functional significance of this differential expression is not fully understood. Desmocollin-1 can be found in the upper layers. The expression of desmocollin-2 varies in the basal and suprabasal layers. And desmocollin-3 is expressed more evenly throughout the suprabasal layers.
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UniProt
- Q02487
抗原
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