CRYAB 抗体 (full length)
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Quick Overview for CRYAB 抗体 (full length) (ABIN7878047)
抗原
See all CRYAB 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- full length
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原理
- Crystallin Alpha B Antibody (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- Recombinant human full-length CRYAB protein was used as the immunogen for the Crystallin Alpha B antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Crystallin Alpha B antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the Crystallin Alpha B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- CRYAB (Crystallin, alpha B (CRYAB))
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别名
- Crystallin Alpha B
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背景
- Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into Alpha, Beta and Gamma families, and the Beta- and Gamma-crystallins also compose a superfamily. Crystallins usually contain seven distinct protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha-crystallins consist of three gene products, AlphaA-, AlphaB- and AlphaC-crystallin, which are members of the small heat shock protein family (HSP 20). Alpha-crystallins act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, Alpha-crystallins do not renature these proteins. Expression of AlphaA-crystallin is restricted to the lens and defects of this gene cause the development of autosomal dominant congenital cataracts (ADCC). The human AlphaB-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of AlphaB-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.
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UniProt
- P02511
抗原
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