Recombinant CD151 抗体 (full length)
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北京 101111
Quick Overview for Recombinant CD151 抗体 (full length) (ABIN7877843)
抗原
See all CD151 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- full length
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原理
- Recombinant CD151 Antibody
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纯化方法
- Protein A/G affinity
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免疫原
- Recombinant full-length human CD151 protein was used as the immunogen for the recombinant CD151 antibody.
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亚型
- IgG, kappa
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应用备注
- Optimal dilution of the recombinant CD151 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the recombinant CD151 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- CD151
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别名
- CD151
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背景
- CD151 is involved in a wide variety of cell biological processes, including cell adhesion and the transport of integrins via vesicles. The human CD151 gene maps to chromosome 11p15.5 and encodes a 253 amino acid protein, which belongs to the tetraspan (4TM) superfamily. CD151 can associate with several integrin chains including beta1, beta3, beta4, alpha2, alpha3, alpha5 and alpha6 integrins. CD151 may provide a framework for the spatial organization of both type I and type II hemidesmosomes, which are specialized junctional complexes that function as cell attachment sites for binding to basement membranes. CD151 RNA transcript (1.6 kb) can be detected in MO7e cells, bone marrow stromal cells, C11 endothelial cells, HUVEC and several myeloid leukemia cell lines, however, no transcript is detected in brain and the lymphoblastoid cell lines MOLT-4 and BALM-1. Leu 149-Glu 213 of CD151 is the interface through which Integrin alpha3/beta1 can bind. CD151 can enhance cell motility, invasion and metastasis of cancer cells in a focal adhesion kinase dependent manner.
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UniProt
- P48509
抗原
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