Calpain 抗体 (full length)
The 小鼠 单克隆 anti-Calpain antibody is suitable to detect Calpain in samples from 人. It has been validated for IHC (p).
产品编号 ABIN7877760
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Quick Overview for Calpain 抗体 (full length) (ABIN7877760)
抗原
Calpain
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This Calpain antibody is un-conjugated
应用范围
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
克隆位点
CAPN1-1530
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抗原表位
- full length
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原理
- Calpain Antibody / CAPN1
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纯化方法
- Protein G affinity chromatography
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免疫原
- A recombinant full-length human CAPN1 protein was used as the immunogen for this Calpain antibody.
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亚型
- IgG1, kappa
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anti-Calpain (AA 396-555), (Catalytic Subunit) antibody
适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Calpain (AA 1-19) antibody适用: 人 WB 宿主: 小鼠 Monoclonal Calp3d-2C4 unconjugated
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应用备注
- Optimal dilution of the Calpain antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the Calpain antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- Calpain
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背景
- Calpain 1 is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+- dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpain 1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.
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UniProt
- P07384
抗原
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