Recombinant beta-2 Microglobulin 抗体 (full length)
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Quick Overview for Recombinant beta-2 Microglobulin 抗体 (full length) (ABIN7877720)
抗原
See all beta-2 Microglobulin (B2M) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- full length
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原理
- Recombinant B2M Antibody / Beta-2 Microglobulin (azide and preservative free)
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纯化方法
- Protein A affinity
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免疫原
- Recombinant full-length human B2M protein was used as the immunogen for the recombinant B2M antibody.
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亚型
- IgG, kappa
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应用备注
- Optimal dilution of the recombinant B2M antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the recombinant B2M antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))
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别名
- B2M
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背景
- Recognizes a protein of 12 kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 Molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 Molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 Molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
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UniProt
- P61769
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途径
- TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
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