BCL11A 抗体 (full length)
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北京 101111
Quick Overview for BCL11A 抗体 (full length) (ABIN7877692)
抗原
See all BCL11A 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- full length
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原理
- BCL11A Antibody / B-cell lymphoma/leukemia 11A (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- Recombinant full-length human protein was used as the immunogen for the BCL11A antibody.
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亚型
- IgG2a
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应用备注
- Optimal dilution of the BCL11A antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the BCL11A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))
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别名
- BCL11A
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背景
- Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.
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UniProt
- Q9H165
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途径
- Regulation of Cell Size
抗原
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