OPN5 抗体 (C-Term)
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Quick Overview for OPN5 抗体 (C-Term) (ABIN7877440)
抗原
See all OPN5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- OPN5 Antibody / Opsin 5 / Neuropsin
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human OPN5 was used as the immunogen for the OPN5 antibody.
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亚型
- IgG
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anti-Opsin 5 (OPN5) (AA 310-353) antibody
OPN5 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Opsin 5 (OPN5) (Transmembrane Domain) antibodyOPN5 适用: 人, 小鼠, Cow, 犬, 马, 兔, 猴, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Opsin 5 (OPN5) (C-Term) antibodyOPN5 适用: 人, Cow, 犬, 马, 兔, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Opsin 5 (OPN5) (C-Term) antibodyOPN5 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, Pig, 豚鼠, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Opsin 5 (OPN5) (C-Term) antibodyOPN5 适用: 人, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Opsin 5 (OPN5) antibodyOPN5 适用: 人 WB, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Opsin 5 (OPN5) (C-Term) antibodyOPN5 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Opsin 5 (OPN5) (AA 200-300) antibodyOPN5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Opsin 5 (OPN5) (AA 205-254) antibodyOPN5 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, Pig, 猴, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Opsin 5 (OPN5) (AA 251-300) antibodyOPN5 适用: 人, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the OPN5 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the OPN5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- OPN5 (Opsin 5 (OPN5))
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别名
- OPN5
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背景
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OPN5 antibody detects Opsin-5 (also known as Neuropsin or G protein-coupled receptor 136), a light-sensitive G protein-coupled receptor involved in non-visual photoreception. Encoded by the OPN5 gene on chromosome 6p12.3, this protein belongs to the opsin family of photoreceptive GPCRs that use retinaldehyde chromophores to detect light. Opsin-5 absorbs near-ultraviolet light and activates intracellular signaling via inhibitory G proteins (Gi/Go), modulating circadian rhythms and neuroendocrine responses independent of classical retinal photoreceptors.
OPN5 is expressed in brain regions such as the hypothalamus and preoptic area, as well as in peripheral tissues including retina, cornea, skin, and reproductive organs. It functions as a UV-sensitive photoreceptor regulating local circadian oscillators and hormone secretion. In the eye, OPN5 contributes to light entrainment of retinal and non-retinal cells, while in the skin and reproductive tissues, it influences seasonal and environmental light-dependent physiology. The receptor's activation triggers G protein signaling that modulates cyclic AMP levels, gene expression, and ion channel activity.
The OPN5 antibody is a valuable tool for neurobiology, circadian rhythm, and sensory physiology research. Western blot analysis detects a 40 kilodalton band corresponding to Opsin-5, while immunofluorescence and immunohistochemistry reveal membrane localization in neuronal and epithelial tissues. This antibody supports the study of light-dependent signaling outside the visual system and enables mapping of Opsin-5 expression across tissues.
Dysregulation of OPN5 signaling has been linked to altered circadian rhythms, hormonal imbalances, and impaired photic entrainment. In animal models, OPN5 influences melatonin secretion and reproductive seasonality, connecting environmental lighting cues to endocrine function. The OPN5 antibody facilitates the exploration of these mechanisms by providing specific detection of Opsin-5 in experimental systems. NSJ Bioreagents offers this antibody validated for its applications, ensuring consistent and high-quality performance for light-sensing and circadian biology research. -
UniProt
- Q6U736
抗原
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