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MARCKS 抗体 (C-Term)

Name: MARCKS 抗体 (C-Term)
SKU: ABIN7877435
Availability: OutOfStock

This 兔多克隆 antibody specifically detects MARCKS in WB, IHC 和 FACS. It exhibits reactivity toward 人, 小鼠和大鼠.

产品编号 ABIN7877435

发货至: 中国

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Quick Overview for MARCKS 抗体 (C-Term) (ABIN7877435)

抗原

See all MARCKS 抗体

MARCKS (Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This MARCKS antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Discover our top product MARCKS Primary Antibody

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C-Term

原理

MARCKS Antibody / Myristoylated alanine-rich C-kinase substrate

纯化方法

Immunogen affinity purified

免疫原

A synthetic peptide corresponding to a sequence at the C-terminus of human MARCKS was used as the immunogen for the MARCKS antibody.

亚型

IgG
anti-Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (AA 2-65) antibody
MARCKS 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2C2 unconjugated

anti-Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (AA 1-100) antibody
MARCKS 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (pSer170) antibody
MARCKS 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (AA 2-66) antibody
MARCKS 适用: 人, 小鼠 WB, ELISA, IF, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2C2 unconjugated

anti-Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (Internal Region) antibody
MARCKS 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (pSer152), (Ser156) antibody
MARCKS 适用: 人, 小鼠, 大鼠, Cow, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated

anti-Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (pSer162) antibody
MARCKS 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (pSer158) antibody
MARCKS 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (AA 31-120) antibody
MARCKS 适用: 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (pSer159) antibody
MARCKS 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal dilution of the MARCKS antibody should be determined by the researcher.

限制

仅限研究用
状态

Lyophilized

溶解方式

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

储存条件

4 °C,-20 °C

储存方法

After reconstitution, the MARCKS antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
抗原

MARCKS (Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS))

别名

MARCKS

背景

MARCKS antibody detects Myristoylated alanine-rich C-kinase substrate, a key substrate of protein kinase C and an essential regulator of the actin cytoskeleton, cell motility, and signal transduction. MARCKS is a prominent peripheral membrane protein that cycles between membrane-bound and cytosolic states depending on phosphorylation and binding to calcium-calmodulin. The MARCKS antibody is used extensively in studies of cellular signaling, cytoskeletal rearrangement, and neuronal plasticity, providing insight into mechanisms that link phosphorylation signaling to membrane-cytoskeleton interactions.

MARCKS is encoded by the MARCKS gene located on human chromosome 6q22.2. The protein is approximately 32 kilodaltons in size and is characterized by a highly basic effector domain that mediates binding to actin filaments, calmodulin, and acidic phospholipids such as phosphatidylinositol 4,5-bisphosphate (PIP2). N-terminal myristoylation allows MARCKS to anchor reversibly to the plasma membrane. Activation of protein kinase C induces phosphorylation of specific serine residues within the effector domain, causing detachment from the membrane and release of bound PIP2, thus modulating downstream calcium signaling and actin polymerization.

Using the MARCKS antibody, researchers can detect phosphorylated and non-phosphorylated forms of the protein by western blot and immunofluorescence. Western blot typically reveals a single band around 32-35 kilodaltons, while phospho-specific variants of MARCKS migrate slower due to phosphorylation-induced charge differences. Immunostaining shows cortical and membrane localization in unphosphorylated states, transitioning to a diffuse cytoplasmic distribution following stimulation with phorbol esters or calcium ionophores. MARCKS plays critical roles in cell migration, exocytosis, phagocytosis, and neuronal growth cone extension, making it a widely studied effector of signal-dependent cytoskeletal remodeling.

In the nervous system, MARCKS regulates dendritic spine morphology, synaptic vesicle trafficking, and axonal guidance. It is enriched in developing neurons and contributes to long-term potentiation and synaptic plasticity. In non-neuronal tissues, MARCKS is implicated in wound healing, immune cell chemotaxis, and cancer metastasis. Overexpression and dysregulation have been observed in glioblastoma, breast cancer, and inflammatory diseases, highlighting its function as a signaling nexus controlling cell motility and proliferation. NSJ Bioreagents provides a validated MARCKS antibody optimized for western blot, immunofluorescence, and immunohistochemistry, supporting detailed analysis of actin dynamics, phosphorylation signaling, and membrane-cytoskeletal coordination.

UniProt

P29966