MYL3/CMLC1 抗体 (C-Term)
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Quick Overview for MYL3/CMLC1 抗体 (C-Term) (ABIN7877434)
抗原
See all MYL3/CMLC1 (MYL3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- MYL3 Antibody / Myosin light chain 3
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human MYL3 was used as the immunogen for the MYL3 antibody.
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亚型
- IgG
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anti-Myosin, Light Chain 3 (MYL3) (AA 5-181) antibody
MYL3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Myosin, Light Chain 3 (MYL3) (AA 8-199) antibodyMYL3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Myosin, Light Chain 3 (MYL3) antibodyMYL3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Myosin, Light Chain 3 (MYL3) (AA 1-195) antibodyMYL3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4C2 unconjugated
anti-Myosin, Light Chain 3 (MYL3) antibodyMYL3 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 3F8 unconjugated
anti-Myosin, Light Chain 3 (MYL3) (Internal Region) antibodyMYL3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myosin, Light Chain 3 (MYL3) (AA 1-195) antibodyMYL3 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Myosin, Light Chain 3 (MYL3) (AA 1-195) antibodyMYL3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Myosin, Light Chain 3 (MYL3) antibodyMYL3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Myosin, Light Chain 3 (MYL3) (N-Term) antibodyMYL3 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the MYL3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MYL3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MYL3/CMLC1 (MYL3) (Myosin, Light Chain 3 (MYL3))
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别名
- MYL3
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背景
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MYL3 antibody detects Myosin light chain 3, a contractile protein component of cardiac and skeletal muscle that modulates actin-myosin interactions during muscle contraction. The UniProt recommended name is Myosin light chain 3 (MYL3). This protein binds to myosin heavy chains and contributes to force generation and sarcomere stability in striated muscle fibers.
Functionally, MYL3 antibody identifies a 151-amino-acid calcium-binding protein localized to the myofilament's thick filament region. MYL3 interacts with the myosin heavy chain alpha isoform and regulates actomyosin ATPase activity through conformational changes induced by calcium binding. It plays a key role in sarcomere assembly, contractile force regulation, and muscle fiber maintenance.
The MYL3 gene is located on chromosome 3p21.31 and is expressed predominantly in ventricular cardiac tissue and slow-twitch skeletal muscles. MYL3 is essential for normal heart contractility and mechanical stability under physiological stress.
Pathologically, mutations in MYL3 cause familial hypertrophic cardiomyopathy and restrictive cardiomyopathy by altering calcium binding and myosin-actin interactions. Defects in MYL3 impair contractile performance and promote myofibrillar disarray. Research using MYL3 antibody supports studies in cardiac physiology, muscle biochemistry, and hereditary myopathies.
MYL3 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect sarcomeric proteins. NSJ Bioreagents provides MYL3 antibody reagents optimized for research in cardiomyocyte biology, muscle contraction, and structural myopathy studies.
Structurally, Myosin light chain 3 belongs to the EF-hand superfamily and contains two calcium-binding motifs that regulate its conformational changes and interaction with myosin. This antibody aids analysis of MYL3's role in cardiac contractility and muscle development. -
UniProt
- P08590
抗原
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