HOXB6 抗体 (C-Term)
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Quick Overview for HOXB6 抗体 (C-Term) (ABIN7877397)
抗原
See all HOXB6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- HOXB6 Antibody / Homeobox protein Hox-B6
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human HOXB6 was used as the immunogen for the HOXB6 antibody.
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亚型
- IgG
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anti-Homeobox B6 (HOXB6) (AA 1-57) antibody
HOXB6 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 8E3 unconjugated
anti-Homeobox B6 (HOXB6) (AA 128-155) antibodyHOXB6 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB24648 unconjugated
anti-Homeobox B6 (HOXB6) (AA 98-131) antibodyHOXB6 适用: 斑马鱼 WB 宿主: 兔 Polyclonal RB49670 unconjugated
anti-Homeobox B6 (HOXB6) (AA 30-110) antibodyHOXB6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Homeobox B6 (HOXB6) (AA 89-138) antibodyHOXB6 适用: 人, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Homeobox B6 (HOXB6) (AA 18-45), (N-Term) antibodyHOXB6 适用: 小鼠 WB 宿主: 兔 Polyclonal RB37120 unconjugated
anti-Homeobox B6 (HOXB6) (AA 135-163), (Middle Region) antibodyHOXB6 适用: 小鼠, 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the HOXB6 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the HOXB6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- HOXB6 (Homeobox B6 (HOXB6))
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别名
- HOXB6
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背景
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HOXB6 antibody recognizes Homeobox protein Hox-B6, a sequence-specific transcription factor that directs developmental patterning and cell differentiation. Encoded by the HOXB6 gene on chromosome 17q21.32, this protein belongs to the homeobox (HOX) family of transcription factors that determine positional identity along the anterior-posterior axis during embryogenesis. HOXB6 contains a highly conserved homeodomain that binds specific DNA sequences to regulate expression of genes involved in morphogenesis, hematopoiesis, and organ development. It acts downstream of retinoic acid signaling and cooperates with cofactors such as PBX1 and MEIS1 to control target gene activation.
During development, HOXB6 expression is restricted to specific regions of the embryo corresponding to the thoracic and lumbar domains. It contributes to the specification of vertebrae and rib patterning and influences limb and neural development. In adult tissues, HOXB6 expression is largely downregulated but can be reactivated in certain cell lineages, particularly within the hematopoietic system. Overexpression of HOXB6 has been observed in leukemias, where it drives proliferation and disrupts differentiation by altering transcriptional programs that control cell fate.
The HOXB6 antibody is a valuable reagent for developmental biology and cancer research. Western blot analysis detects a 25 kilodalton band corresponding to HOXB6, and immunohistochemical staining shows nuclear localization consistent with its role as a transcription factor. The antibody supports studies examining HOX gene regulation, retinoic acid signaling, and transcriptional networks controlling tissue differentiation. In experimental systems, HOXB6 expression is used as a marker of posterior HOX cluster activation, which defines segmental identity and developmental timing.
Functionally, HOXB6 binds to enhancer regions of genes that regulate cell cycle progression and differentiation, including MYC and CDKN1A. Dysregulation of HOXB6 is implicated in oncogenesis, particularly in acute myeloid leukemia, where it cooperates with MEIS1 to promote leukemic transformation. In solid tumors, aberrant HOXB6 expression correlates with invasive potential and epithelial-mesenchymal transition. The HOXB6 antibody facilitates detection of these expression changes, enabling characterization of HOX-mediated gene regulation in both normal and malignant cells. NSJ Bioreagents provides this antibody validated for its applications, supporting research into developmental biology and transcriptional control. -
UniProt
- P17509
抗原
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