GZMM 抗体 (C-Term)
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Quick Overview for GZMM 抗体 (C-Term) (ABIN7877389)
抗原
See all GZMM 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- GZMM Antibody / Granzyme M
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human Granzyme M/GZMM was used as the immunogen for the GZMM antibody.
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亚型
- IgG
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anti-Granzyme M (Lymphocyte Met-Ase 1) (GZMM) antibody
GZMM 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Granzyme M (Lymphocyte Met-Ase 1) (GZMM) (AA 84-113) antibodyGZMM 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB19358 unconjugated
anti-Granzyme M (Lymphocyte Met-Ase 1) (GZMM) (AA 26-257) antibodyGZMM 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Granzyme M (Lymphocyte Met-Ase 1) (GZMM) antibodyGZMM 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Granzyme M (Lymphocyte Met-Ase 1) (GZMM) (AA 26-257) antibodyGZMM 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal D1 unconjugated
anti-Granzyme M (Lymphocyte Met-Ase 1) (GZMM) (AA 85-193) antibodyGZMM 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4D11 unconjugated
anti-Granzyme M (Lymphocyte Met-Ase 1) (GZMM) (AA 98-243) antibodyGZMM 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Granzyme M (Lymphocyte Met-Ase 1) (GZMM) antibodyGZMM 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Granzyme M (Lymphocyte Met-Ase 1) (GZMM) (AA 31-257) antibodyGZMM 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Granzyme M (Lymphocyte Met-Ase 1) (GZMM) (AA 19-251) antibodyGZMM 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GZMM antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GZMM antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GZMM (Granzyme M (Lymphocyte Met-Ase 1) (GZMM))
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别名
- GZMM
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背景
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GZMM antibody detects Granzyme M, a serine protease expressed in cytotoxic lymphocytes and natural killer (NK) cells that mediates immune defense through target cell apoptosis. The UniProt recommended name is Granzyme M (GZMM). This enzyme contributes to innate immunity by inducing non-caspase-dependent cell death and by modulating inflammatory cytokine processing.
Functionally, GZMM antibody identifies a 262-amino-acid protein localized to cytotoxic granules of NK and CD8+ T cells. Granzyme M is stored in secretory vesicles and released upon immune activation to cleave intracellular substrates in infected or malignant cells. It works synergistically with perforin and other granzymes to initiate rapid target cell lysis.
The GZMM gene is located on chromosome 19p13.3 within the granzyme gene cluster and is expressed predominantly in NK cells and cytotoxic T lymphocytes. GZMM contributes to immune surveillance by degrading viral and bacterial proteins and modulating proinflammatory signaling pathways.
Pathologically, elevated GZMM activity has been observed in inflammatory and autoimmune diseases, as well as in cancer immune responses. Deficiency impairs cytotoxic clearance of pathogens and tumor cells. Research using GZMM antibody supports studies in immunology, cytotoxic signaling, and inflammation control.
GZMM antibody is validated for western blotting, flow cytometry, and immunohistochemistry to detect cytotoxic granule enzymes. NSJ Bioreagents provides GZMM antibody reagents optimized for immune cell function, cytotoxicity, and inflammation research.
Structurally, Granzyme M is a trypsin-like serine protease containing the catalytic triad His-Asp-Ser and a substrate-binding pocket that determines cleavage specificity. This antibody aids in examining GZMM's role in cytotoxic defense and immune regulation. -
UniProt
- P51124
抗原
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