DDC 抗体 (C-Term)
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Quick Overview for DDC 抗体 (C-Term) (ABIN7877360)
抗原
See all DDC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- DDC Antibody / DOPA decarboxylase
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human DOPA decarboxylase/DDC was used as the immunogen for the DDC antibody.
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亚型
- IgG
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anti-Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) (AA 1-100) antibody
DDC 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) (AA 32-61), (N-Term) antibodyDDC 适用: 人, 小鼠 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB21702 unconjugated
anti-Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) (AA 201-300) antibodyDDC 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) (AA 200-420) antibodyDDC 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) (AA 1-480) antibodyDDC 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 8E8 unconjugated
anti-Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) antibodyMicroarray verified DDC 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB783620 unconjugated
anti-Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) (N-Term) antibodyDDC 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 兔, 马, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) (AA 1-480) antibodyDDC 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) antibodyDDC 适用: 人, 小鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC) (N-Term) antibodyDDC 适用: 人, 小鼠, 犬, 豚鼠, 马, 猴, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the DDC antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the DDC antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))
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别名
- DDC
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背景
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DDC antibody detects Aromatic-L-amino-acid decarboxylase, encoded by the DDC gene on chromosome 7p12.2. DDC antibody is widely used in neuroscience, metabolism, and clinical disorder research. DDC, also known as DOPA decarboxylase, catalyzes the decarboxylation of L-DOPA to dopamine and 5-hydroxytryptophan to serotonin, two critical neurotransmitters. By driving these biosynthetic steps, DDC plays a central role in catecholamine and serotonin metabolism, influencing behavior, cognition, and autonomic function.
Structurally, DDC is a ~53 kDa pyridoxal phosphate-dependent enzyme that functions as a homodimer. It contains a conserved active site lysine that forms a Schiff base with pyridoxal phosphate, essential for decarboxylation. The enzyme is localized to cytoplasm in neurons, endocrine cells, and peripheral tissues where neurotransmitter precursors are available.
Functionally, DDC is indispensable for synthesis of dopamine, norepinephrine, epinephrine, and serotonin. Its activity links amino acid metabolism with neurotransmission and hormone regulation. In the brain, DDC activity influences motor control, mood, and cognition. In peripheral tissues, it contributes to endocrine signaling and metabolic control. Researchers use DDC antibody to study neurotransmitter biosynthesis, psychiatric disease, and neurodegeneration.
Clinically, mutations in DDC cause aromatic L-amino acid decarboxylase deficiency, a rare metabolic disorder characterized by developmental delay, hypotonia, movement abnormalities, and autonomic dysfunction. DDC activity is also relevant in Parkinson's disease, where it influences dopamine availability and responsiveness to L-DOPA therapy. Dysregulated DDC expression has been linked to psychiatric disorders, endocrine diseases, and cancer. NSJ Bioreagents provides DDC antibody for neuroscience, metabolism, and clinical disorder research.
Experimentally, DDC antibody is applied in western blotting to detect the ~53 kDa enzyme, in immunohistochemistry to study expression in brain and endocrine tissues, and in immunofluorescence to localize cytoplasmic protein. Enzyme assays paired with DDC antibody confirm catalytic function in cell and tissue extracts. -
UniProt
- P20711
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途径
- Dopaminergic Neurogenesis
抗原
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