CRH 抗体 (C-Term)
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Quick Overview for CRH 抗体 (C-Term) (ABIN7877355)
抗原
See all CRH 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- CRH Antibody / Corticotropin Releasing Hormone
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human CRF/CRH was used as the immunogen for the CRH antibody.
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亚型
- IgG
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anti-Corticotropin Releasing Hormone (CRH) (AA 40-195) antibody
CRH 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Corticotropin Releasing Hormone (CRH) (N-Term) antibodyCRH 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Corticotropin Releasing Hormone (CRH) (AA 154-196) antibodyCRH 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2B11 unconjugated
anti-Corticotropin Releasing Hormone (CRH) (AA 39-187) antibodyCRH 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Corticotropin Releasing Hormone (CRH) antibodyMicroarray verified CRH 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB189288 unconjugated
anti-Corticotropin Releasing Hormone (CRH) antibodyMicroarray verified CRH 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB701026 unconjugated
anti-Corticotropin Releasing Hormone (CRH) (AA 185-196) antibodyCRH 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Corticotropin Releasing Hormone (CRH) (AA 25-194) antibodyCRH 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Corticotropin Releasing Hormone (CRH) antibodyMicroarray verified CRH 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB561789 unconjugated
anti-Corticotropin Releasing Hormone (CRH) (AA 28-160) antibodyCRH 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the CRH antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the CRH antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- CRH (Corticotropin Releasing Hormone (CRH))
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别名
- CRH
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背景
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CRH antibody detects Corticotropin releasing hormone, a neuropeptide hormone that regulates the hypothalamic-pituitary-adrenal (HPA) axis and stress response. The UniProt recommended name is Corticotropin releasing hormone (CRH). This 41-amino-acid peptide is synthesized in the hypothalamus and secreted into the hypophyseal portal circulation, where it stimulates adrenocorticotropic hormone (ACTH) release from the anterior pituitary.
Functionally, CRH antibody identifies the peptide precursor prepro-CRH, which undergoes proteolytic cleavage to produce the mature active hormone. CRH binds to G protein-coupled receptors CRHR1 and CRHR2 on pituitary corticotrophs, activating adenylate cyclase and cAMP-dependent signaling pathways that induce ACTH synthesis and secretion. ACTH in turn stimulates cortisol release from the adrenal cortex, completing the neuroendocrine feedback loop that maintains stress adaptation and homeostasis.
The CRH gene is located on chromosome 8q13.1 and is primarily expressed in the paraventricular nucleus of the hypothalamus, but also in peripheral tissues such as the placenta, adrenal glands, and gastrointestinal tract. CRH coordinates endocrine, autonomic, and behavioral responses to stress, linking neuroendocrine signaling with emotional and metabolic regulation.
Pathologically, dysregulated CRH expression is associated with anxiety, depression, Cushingi 1/2s syndrome, and inflammatory disorders. Overproduction of CRH leads to chronic activation of the HPA axis and elevated cortisol levels, while deficiency impairs stress response and adrenal function. Research using CRH antibody supports studies in neuroendocrinology, stress physiology, and behavioral neuroscience.
CRH antibody is validated for immunohistochemistry, ELISA, and immunofluorescence to detect neuropeptides and hormones. NSJ Bioreagents provides CRH antibody reagents optimized for research in endocrine signaling, stress regulation, and hypothalamic function.
Structurally, Corticotropin releasing hormone is a 41-residue peptide containing a disulfide bond that stabilizes its helical structure, essential for receptor binding and biological activity. Its precursor includes a signal peptide directing secretion and prohormone regions involved in processing. This antibody enables investigation of CRH's role in HPA axis regulation, neuropeptide signaling, and stress-related disorders. -
UniProt
- P06850
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途径
- Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Feeding Behaviour
抗原
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