ARL2 抗体 (C-Term)
Our Local Distributor
北京 101111
Quick Overview for ARL2 抗体 (C-Term) (ABIN7877310)
抗原
See all ARL2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
原理
- ARL2 Antibody / ADP-ribosylation factor-like protein 2
-
纯化方法
- Immunogen affinity purified
-
免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human ARL2 was used as the immunogen for the ARL2 antibody.
-
亚型
- IgG
-
-
anti-ADP-Ribosylation Factor-Like 2 (ARL2) (C-Term) antibody
Verified ARL2 适用: 人 WB, ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-ADP-Ribosylation Factor-Like 2 (ARL2) (AA 155-184), (C-Term) antibodyARL2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB5092 unconjugated
anti-ADP-Ribosylation Factor-Like 2 (ARL2) (AA 1-184) antibodyARL2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-ADP-Ribosylation Factor-Like 2 (ARL2) antibodyARL2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-ADP-Ribosylation Factor-Like 2 (ARL2) (AA 19-184) antibodyARL2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-ADP-Ribosylation Factor-Like 2 (ARL2) antibodyARL2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-ADP-Ribosylation Factor-Like 2 (ARL2) (AA 1-184) antibodyARL2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-ADP-Ribosylation Factor-Like 2 (ARL2) (C-Term) antibodyARL2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-ADP-Ribosylation Factor-Like 2 (ARL2) (AA 53-82), (Middle Region) antibodyARL2 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
anti-ADP-Ribosylation Factor-Like 2 (ARL2) (AA 123-184) antibodyARL2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the ARL2 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the ARL2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- ARL2 (ADP-Ribosylation Factor-Like 2 (ARL2))
-
别名
- ARL2
-
背景
-
ARL2 antibody detects ADP-ribosylation factor-like protein 2, a small GTP-binding protein involved in microtubule dynamics, mitochondrial function, and intracellular transport. Encoded by the ARL2 gene on chromosome 11q13.2, this evolutionarily conserved member of the ARF family of GTPases cycles between active GTP-bound and inactive GDP-bound states to regulate cytoskeletal organization and vesicle trafficking. ARL2 participates in essential cellular processes ranging from ciliary assembly to energy metabolism.
Structurally, ARL2 is a 184-amino-acid cytosolic protein of approximately 21 kilodaltons containing the characteristic GTP-binding motifs (G1-G5 boxes) required for nucleotide exchange and hydrolysis. It interacts with cofactors such as cofactor D (TBCD) and cofactor E (TBCE) to modulate tubulin folding and polymerization. ARL2 localizes to both cytoplasm and mitochondria, where it forms complexes that support microtubule stability and mitochondrial fusion.
The ARL2 antibody is widely used in cell biology, neurobiology, and mitochondrial research to study small GTPase signaling, cytoskeletal organization, and intracellular trafficking. Western blot analysis detects a 21 kilodalton band corresponding to ARL2, while immunofluorescence demonstrates cytoplasmic and mitochondrial staining patterns. This antibody provides a dependable tool for monitoring ARL2-mediated control of tubulin dynamics and organelle function.
Functionally, ARL2 regulates the folding of alpha and beta tubulin heterodimers, supporting microtubule assembly critical for intracellular transport and cell division. Within mitochondria, ARL2 influences fusion, morphology, and ATP production by interacting with proteins such as ANT1 and ELMOD2. Dysregulation of ARL2 expression affects mitochondrial integrity, axonal transport, and cell viability. In neurons, ARL2 contributes to microtubule-based trafficking of synaptic vesicles and organelles. The ARL2 antibody enables analysis of these processes and provides insights into cytoskeletal and metabolic coordination. NSJ Bioreagents validates this antibody for its applications, ensuring reliable and sensitive detection for GTPase and mitochondrial studies. -
UniProt
- P36404
-
途径
- Cell-Cell Junction Organization, Maintenance of Protein Location
抗原
-
