ENTPD5 抗体 (AA 95-428)
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北京 101111
Quick Overview for ENTPD5 抗体 (AA 95-428) (ABIN7877223)
抗原
See all ENTPD5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 95-428
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原理
- ENTPD5 Antibody / Ectonucleoside triphosphate diphosphohydrolase 5
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human ENTPD5 recombinant protein (Position: D95-H428) was used as the immunogen for the ENTPD5 antibody.
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亚型
- IgG
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anti-Ectonucleoside Triphosphate diphosphohydrolase 5 (ENTPD5) (Center) antibody
ENTPD5 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 5 (ENTPD5) antibodyENTPD5 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 5 (ENTPD5) (AA 149-428) antibodyENTPD5 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 5 (ENTPD5) (AA 319-400) antibodyENTPD5 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4A5 unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 5 (ENTPD5) (AA 331-380) antibodyENTPD5 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 5 (ENTPD5) antibodyENTPD5 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 5 (ENTPD5) antibodyENTPD5 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 5 (ENTPD5) (AA 319-400) antibodyENTPD5 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 5 (ENTPD5) (AA 85-134) antibodyENTPD5 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Ectonucleoside Triphosphate diphosphohydrolase 5 (ENTPD5) (AA 333-362), (C-Term) antibodyENTPD5 适用: 人 WB 宿主: 兔 Polyclonal RB39795 unconjugated
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应用备注
- Optimal dilution of the ENTPD5 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the ENTPD5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- ENTPD5 (Ectonucleoside Triphosphate diphosphohydrolase 5 (ENTPD5))
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别名
- ENTPD5
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背景
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ENTPD5 antibody detects Ectonucleoside triphosphate diphosphohydrolase 5, an endoplasmic reticulum (ER)-localized enzyme that regulates protein N-glycosylation and energy metabolism. The UniProt recommended name is Ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5). Unlike other ENTPD family members that function extracellularly, ENTPD5 acts within the ER lumen, promoting protein folding and glycoprotein maturation through its unique enzymatic cycle.
Functionally, ENTPD5 antibody identifies a 428-amino-acid enzyme that hydrolyzes UDP and GDP to UMP and GMP, coupling its activity to the UDP-glucose pyrophosphorylase reaction that regenerates UDP-glucose. This cycle supports proper glycoprotein processing by maintaining a continuous supply of glycosylation precursors within the ER. ENTPD5 activity enhances protein folding capacity and assists in the maturation of membrane receptors and secretory proteins.
The ENTPD5 gene is located on chromosome 14q24.1 and is expressed in metabolically active tissues such as liver, pancreas, and muscle. Its expression is transcriptionally upregulated by AKT signaling and MYC oncogene activation, linking metabolic reprogramming to cancer cell growth. ENTPD5 contributes to the Warburg effect by coupling glycosylation demand to glycolytic flux in proliferating cells.
Pathologically, overexpression of ENTPD5 promotes tumor progression by increasing glycoprotein folding and surface receptor stability, enhancing proliferative signaling. Conversely, loss of ENTPD5 impairs growth factor receptor maturation and induces ER stress. Elevated ENTPD5 expression has been observed in prostate, colon, and liver cancers. Research using ENTPD5 antibody supports studies in cancer metabolism, glycoprotein folding, and ER homeostasis.
ENTPD5 antibody is validated for western blotting, immunohistochemistry, and ELISA to detect ER-localized glycoprotein processing enzymes. NSJ Bioreagents provides ENTPD5 antibody reagents optimized for studies in protein maturation, metabolic regulation, and oncogenic signaling.
Structurally, Ectonucleoside triphosphate diphosphohydrolase 5 contains an apyrase conserved region (ACR) and calcium-binding motifs essential for nucleotide hydrolysis. It forms dimers in the ER lumen and associates with chaperones such as calnexin and calreticulin. This antibody enables exploration of ENTPD5's role in glycoprotein biosynthesis, ER stress adaptation, and cancer metabolism. -
UniProt
- O75356
抗原
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