STRIP1 抗体 (AA 93-511)
Our Local Distributor
北京 101111
Quick Overview for STRIP1 抗体 (AA 93-511) (ABIN7877185)
抗原
See all STRIP1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 93-511
-
原理
- STRIP1 Antibody / Striatin-interacting protein 1
-
纯化方法
- Immunogen affinity purified
-
免疫原
- E.coli-derived human STRIP1 recombinant protein (Position: E93-Q511) was used as the immunogen for the STRIP1 antibody.
-
亚型
- IgG
-
-
anti-Striatin Interacting Protein 1 (STRIP1) antibody
STRIP1 适用: 人, 大鼠, 犬, 猴 WB, FACS, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 7B8 unconjugated
anti-Striatin Interacting Protein 1 (STRIP1) (AA 352-381) antibodySTRIP1 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB24156 unconjugated
anti-Striatin Interacting Protein 1 (STRIP1) (AA 359-389), (Middle Region) antibodySTRIP1 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Striatin Interacting Protein 1 (STRIP1) (AA 255-360) antibodySTRIP1 适用: 人 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Striatin Interacting Protein 1 (STRIP1) (AA 25-75) antibodySTRIP1 适用: 人, 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Striatin Interacting Protein 1 (STRIP1) (AA 743-837) antibodySTRIP1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the STRIP1 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the STRIP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- STRIP1 (Striatin Interacting Protein 1 (STRIP1))
-
别名
- STRIP1
-
背景
-
STRIP1 antibody detects Striatin-interacting protein 1, a core component of the STRIPAK complex that integrates signaling, cytoskeletal organization, and cell migration. STRIP1 acts as a scaffold linking the PP2A phosphatase complex with kinases, adaptors, and actin-regulating proteins. The STRIP1 antibody is widely used in cell signaling, neurobiology, and cancer research to study cytoskeletal remodeling, phosphatase signaling, and morphogenesis.
STRIP1 is encoded by the STRIP1 gene located on human chromosome 3q22.1. The protein is approximately 837 amino acids long and forms stable interactions with striatin, PP2A, MOB4, and kinases of the GCKIII family. STRIP1 localizes to both cytoplasmic and cortical compartments, particularly in regions of actin remodeling and cell junctions.
The STRIP1 antibody detects a 95 kilodalton protein by western blot and exhibits perinuclear and cortical staining by immunofluorescence microscopy. STRIP1 regulates the activity of PP2A-dependent phosphatase signaling pathways that control cell polarity, adhesion, and migration. It acts in concert with STRN3 and STRN4 to modulate kinases such as STK24 and STK25, thereby maintaining cytoskeletal balance and tissue architecture.
Disruption of STRIP1 impairs cell migration and polarity, leading to developmental abnormalities and cancer metastasis. Studies show that loss of STRIP1 alters actin stress fiber organization and cell junction stability, while overexpression promotes invasive behavior in tumor cells. In neurons, STRIP1 contributes to dendritic spine morphogenesis and synaptic plasticity through modulation of PP2A and Rho GTPase signaling.
Because STRIP1 functions as a molecular integrator connecting phosphatase signaling with cytoskeletal regulation, it serves as a crucial factor in understanding morphogenesis and disease progression. NSJ Bioreagents provides a validated STRIP1 antibody optimized for its applications, supporting research into cytoskeletal dynamics, PP2A signaling, and cancer biology. -
UniProt
- Q5VSL9
抗原
-
