PRPF18 抗体 (AA 93-342)
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Quick Overview for PRPF18 抗体 (AA 93-342) (ABIN7877181)
抗原
See all PRPF18 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 93-342
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原理
- Zebrafish Prpf18 Antibody / Pre-mRNA-splicing factor 18
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Prpf18 recombinant protein (amino acids E93-L342) was used as the immunogen for the Zebrafish Prpf18 antibody.
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亚型
- Ig Fraction
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anti-PRP18 Pre-mRNA Processing Factor 18 (PRPF18) (AA 1-342) antibody
PRPF18 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-PRP18 Pre-mRNA Processing Factor 18 (PRPF18) (Internal Region) antibodyPRPF18 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-PRP18 Pre-mRNA Processing Factor 18 (PRPF18) (Internal Region) antibodyPRPF18 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-PRP18 Pre-mRNA Processing Factor 18 (PRPF18) (Internal Region) antibodyPRPF18 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-PRP18 Pre-mRNA Processing Factor 18 (PRPF18) (N-Term) antibodyPRPF18 适用: 人, 大鼠, 犬, 豚鼠, 马, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-PRP18 Pre-mRNA Processing Factor 18 (PRPF18) (AA 93-342) antibodyPRPF18 适用: 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Zebrafish Prpf18 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Prpf18 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PRPF18 (PRP18 Pre-mRNA Processing Factor 18 (PRPF18))
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别名
- Prpf18
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背景
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Prpf18 (Pre-mRNA processing factor 18) is a key component of the spliceosome, the large ribonucleoprotein complex responsible for the removal of introns from precursor messenger RNA during gene expression. Prpf18 plays an essential role in the second catalytic step of splicing, contributing to the proper assembly and function of the spliceosomal complex and ensuring the accuracy of mRNA processing.
In zebrafish, Prpf18 is an ortholog of the human PRPF18 gene. The zebrafish and human proteins are highly conserved, particularly within domains essential for spliceosomal interactions and catalytic activity. This conservation suggests functional equivalency between species, making zebrafish a relevant model for studying pre-mRNA splicing and its regulation in development and disease.
Zebrafish Prpf18 may have isoforms arising from alternative splicing events, although isoform-specific functions are still under investigation. The presence of multiple isoforms may allow differential regulation of splicing in a tissue-specific or developmental stage-specific manner.
During zebrafish embryogenesis, Prpf18 is broadly expressed, with notable enrichment in rapidly dividing and transcriptionally active tissues such as the neural tube and developing somites. Its expression is crucial for early development, as disruption of splicing machinery can lead to widespread defects in gene regulation, cell cycle control, and differentiation.
Given its central role in RNA splicing, zebrafish Prpf18 is important for studies related to gene expression regulation, developmental biology, and spliceosome-associated disorders. It also serves as a useful model for understanding human genetic diseases caused by splicing defects, including certain neurodegenerative and retinal disorders.
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UniProt
- Q6GMH0
抗原
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