PIWIL3 抗体 (AA 91-747)
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Quick Overview for PIWIL3 抗体 (AA 91-747) (ABIN7877146)
抗原
See all PIWIL3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 91-747
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原理
- PIWIL3 Antibody / Piwi like protein 3
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human PIWIL3 recombinant protein (Position: Q91-K747) was used as the immunogen for the PIWIL3 antibody.
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亚型
- IgG
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anti-Piwi-Like 3 (PIWIL3) antibody
PIWIL3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Piwi-Like 3 (PIWIL3) (AA 1-882) antibodyPIWIL3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Piwi-Like 3 (PIWIL3) (N-Term) antibodyPIWIL3 适用: 人, 小鼠, 大鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PIWIL3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PIWIL3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PIWIL3 (Piwi-Like 3 (PIWIL3))
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别名
- PIWIL3
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背景
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PIWIL3 antibody detects Piwi like protein 3, encoded by the PIWIL3 gene. Piwi like protein 3 belongs to the Argonaute family of proteins and plays a critical role in germline development, small RNA regulation, and maintenance of genomic integrity. PIWIL3 antibody provides researchers with a specialized reagent for studying piRNA pathways, transposon silencing, and fertility biology.
Piwi like protein 3 is predominantly expressed in oocytes and early embryos, where it participates in RNA silencing through interaction with piRNAs. Research using PIWIL3 antibody has shown that it forms ribonucleoprotein complexes that suppress transposable elements, protecting genome stability during germline development. Its activity helps ensure faithful transmission of genetic material to the next generation.
Studies with PIWIL3 antibody have revealed that this protein contributes to oocyte maturation and embryonic development. It works in conjunction with other PIWI family proteins to organize RNA regulatory pathways essential for fertility. Loss of PIWIL3 activity disrupts piRNA pathways, leading to increased transposon mobilization, DNA damage, and impaired germline development.
Dysregulation of Piwi like protein 3 has been associated with infertility and reproductive failure. Research using PIWIL3 antibody has shown that reduced expression contributes to compromised oocyte quality and embryonic arrest, while altered expression patterns may also play roles in ovarian cancer. These findings highlight its importance in both developmental and disease contexts.
PIWIL3 antibody is widely used in immunohistochemistry, western blotting, and immunofluorescence. Immunohistochemistry identifies localization in ovarian tissue, western blotting quantifies expression during germ cell development, and immunofluorescence highlights piRNA granule distribution in oocytes. These applications make PIWIL3 antibody indispensable for reproductive biology research.
By supplying validated PIWIL3 antibody reagents, NSJ Bioreagents supports studies into small RNA pathways, transposon control, and germline development. Detection of Piwi like protein 3 provides researchers with insight into how piRNA machinery regulates genome stability and reproductive success. -
UniProt
- Q7Z3Z3
抗原
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