GSTO1 抗体 (AA 91-240)
Our Local Distributor
北京 101111
Quick Overview for GSTO1 抗体 (AA 91-240) (ABIN7877139)
抗原
See all GSTO1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 91-240
-
原理
- GSTO1 Antibody / Glutathione S-transferase omega 1
-
纯化方法
- Immunogen affinity purified
-
免疫原
- E.coli-derived mouse GSTO1 recombinant protein (Position: E91-L240) was used as the immunogen for the GSTO1 antibody.
-
亚型
- IgG
-
-
anti-Glutathione S-Transferase omega 1 (GSTO1) (AA 1-241) antibody
GSTO1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Glutathione S-Transferase omega 1 (GSTO1) (AA 24-233) antibodyGSTO1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Glutathione S-Transferase omega 1 (GSTO1) (AA 126-155) antibodyGSTO1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20732 unconjugated
anti-Glutathione S-Transferase omega 1 (GSTO1) (AA 121-209) antibodyGSTO1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Glutathione S-Transferase omega 1 (GSTO1) antibodyGSTO1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Monoclonal 2C7 unconjugated Recombinant Antibody
anti-Glutathione S-Transferase omega 1 (GSTO1) (AA 121-209) antibodyGSTO1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3D9 unconjugated
anti-Glutathione S-Transferase omega 1 (GSTO1) antibodyKO Validated GSTO1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3120 unconjugated Recombinant Antibody
anti-Glutathione S-Transferase omega 1 (GSTO1) antibodyKO Validated GSTO1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutathione S-Transferase omega 1 (GSTO1) (AA 121-209) antibodyGSTO1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B6 unconjugated
anti-Glutathione S-Transferase omega 1 (GSTO1) antibodyGSTO1 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the GSTO1 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the GSTO1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- GSTO1 (Glutathione S-Transferase omega 1 (GSTO1))
-
别名
- GSTO1
-
背景
-
GSTO1 antibody detects Glutathione S-transferase omega-1, an enzyme belonging to the omega class of the glutathione transferase family. GSTO1 catalyzes reduction reactions and participates in antioxidant defense, detoxification, and redox homeostasis. Unlike classical GSTs, GSTO1 possesses dehydroascorbate reductase and deglutathionylase activities, enabling control of oxidative stress and protein thiol status. The GSTO1 antibody is widely used to study redox signaling, neurodegeneration, and inflammation.
GSTO1 is encoded by the GSTO1 gene located on human chromosome 10q25.1. The protein is approximately 28 kilodaltons and features a cysteine residue in the active site instead of the usual serine or tyrosine found in other GSTs. This cysteine enables formation of mixed disulfides with substrates, granting GSTO1 unique catalytic and regulatory properties. The enzyme is mainly cytosolic but can associate with mitochondria and the endoplasmic reticulum during oxidative stress.
The GSTO1 antibody identifies a 28 kilodalton band in western blot analysis and shows cytoplasmic distribution with enrichment in stress-responsive cells. GSTO1 reduces dehydroascorbate to ascorbic acid, maintaining vitamin C pools, and catalyzes deglutathionylation of oxidized proteins to restore function. It also contributes to mercury detoxification and participates in inflammatory signaling through modulation of interleukin-1beta processing.
Variants in GSTO1 have been associated with altered susceptibility to Alzheimer's disease, Parkinson's disease, and certain cancers. By regulating redox balance and apoptosis, GSTO1 influences cellular survival and aging processes. Elevated expression is often observed in tumors and immune cells undergoing oxidative stress, whereas inhibition sensitizes cells to reactive oxygen species-induced death.
GSTO1 is an important biomarker for antioxidant capacity and inflammatory regulation. Its enzymatic versatility links metabolism, detoxification, and immunity. NSJ Bioreagents provides a validated GSTO1 antibody optimized for its applications, supporting research into redox signaling, metabolic adaptation, and neuroinflammation. -
UniProt
- O09131
-
途径
- Myometrial Relaxation and Contraction, Negative Regulation of Transporter Activity
抗原
-
