SHMT2 抗体 (AA 9-504)
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北京 101111
Quick Overview for SHMT2 抗体 (AA 9-504) (ABIN7877091)
抗原
See all SHMT2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 9-504
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原理
- SHMT2 Antibody / Serine hydroxymethyltransferase
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SHMT2 recombinant protein (Position: A9-H504) was used as the immunogen for the SHMT2 antibody.
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亚型
- IgG
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anti-serine Hydroxymethyltransferase 2 (Mitochondrial) (SHMT2) (AA 30-504) antibody
SHMT2 适用: 人 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-serine Hydroxymethyltransferase 2 (Mitochondrial) (SHMT2) (AA 265-504) antibodySHMT2 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-serine Hydroxymethyltransferase 2 (Mitochondrial) (SHMT2) (AA 1-504) antibodySHMT2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-serine Hydroxymethyltransferase 2 (Mitochondrial) (SHMT2) (AA 401-503) antibodySHMT2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5E7 unconjugated
anti-serine Hydroxymethyltransferase 2 (Mitochondrial) (SHMT2) antibodySHMT2 适用: 人, 小鼠, 大鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-serine Hydroxymethyltransferase 2 (Mitochondrial) (SHMT2) (C-Term) antibodySHMT2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-serine Hydroxymethyltransferase 2 (Mitochondrial) (SHMT2) (AA 72-121) antibodySHMT2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, Cow, 斑马鱼, Bat, Hamster, 猴, Pig, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-serine Hydroxymethyltransferase 2 (Mitochondrial) (SHMT2) (AA 401-450) antibodySHMT2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, Bat, Hamster, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-serine Hydroxymethyltransferase 2 (Mitochondrial) (SHMT2) (N-Term) antibodySHMT2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, Cow, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-serine Hydroxymethyltransferase 2 (Mitochondrial) (SHMT2) antibodySHMT2 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SHMT2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SHMT2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SHMT2 (serine Hydroxymethyltransferase 2 (Mitochondrial) (SHMT2))
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别名
- SHMT2
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背景
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The SHMT2 antibody targets Serine hydroxymethyltransferase, mitochondrial, an enzyme encoded by the SHMT2 gene that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylenetetrahydrofolate. This reaction is central to one-carbon metabolism, providing key intermediates for nucleotide synthesis, methylation reactions, and redox regulation. Serine hydroxymethyltransferase, mitochondrial operates within the mitochondrial folate cycle and contributes to biosynthetic and energetic demands in proliferating cells. The SHMT2 antibody provides a reliable reagent for studying one-carbon metabolism, mitochondrial function, and cancer metabolism.
Serine hydroxymethyltransferase, mitochondrial forms homotetramers that utilize pyridoxal phosphate (PLP) as a cofactor for catalysis. Its activity links amino acid metabolism with folate-mediated one-carbon flux, coordinating mitochondrial and cytosolic metabolic networks. The SHMT2 antibody enables visualization of this enzyme within mitochondria, supporting studies of its spatial regulation and contribution to biosynthetic pathways under nutrient limitation or hypoxic conditions. SHMT2 expression increases in rapidly dividing cells to sustain nucleotide production and redox balance.
Aberrant activation of one-carbon metabolism, including SHMT2 upregulation, is a hallmark of cancer metabolism. Overexpression of Serine hydroxymethyltransferase, mitochondrial enhances proliferation and resistance to oxidative stress by supplying reduced folate cofactors and NADPH. The SHMT2 antibody facilitates detection of this metabolic enzyme in tumor tissues and cell lines, aiding evaluation of its role in tumorigenesis and metabolic adaptation. SHMT2 has been proposed as a potential therapeutic target, as inhibition disrupts nucleotide synthesis and redox homeostasis in cancer cells.
Beyond oncology, Serine hydroxymethyltransferase, mitochondrial contributes to neural development, mitochondrial respiration, and cellular methylation capacity. It provides one-carbon units necessary for formate generation and DNA methylation reactions that influence epigenetic regulation. The SHMT2 antibody supports research into these metabolic control points, enabling functional analysis of folate cycle dynamics in metabolic disorders, neurodegenerative diseases, and aging.
The SHMT2 antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, showing clear mitochondrial staining patterns. NSJ Bioreagents provides this antibody with validated specificity for consistent performance in biochemistry, metabolism, and cancer biology research. By enabling detailed study of Serine hydroxymethyltransferase, mitochondrial expression and activity, the SHMT2 antibody supports discovery into one-carbon metabolism and mitochondrial regulation under physiological and pathological conditions. -
UniProt
- P34897
抗原
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