STXBP6 抗体 (AA 9-176)
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Quick Overview for STXBP6 抗体 (AA 9-176) (ABIN7877066)
抗原
See all STXBP6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 9-176
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原理
- STXBP6 Antibody / Syntaxin-binding protein 6
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human STXBP6 recombinant protein (Position: K9-R176) was used as the immunogen for the STXBP6 antibody.
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亚型
- IgG
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anti-Syntaxin Binding Protein 6 (Amisyn) (STXBP6) (AA 2-210) antibody
STXBP6 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin Binding Protein 6 (Amisyn) (STXBP6) (N-Term) antibodySTXBP6 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin Binding Protein 6 (Amisyn) (STXBP6) (N-Term) antibodyVerified STXBP6 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Syntaxin Binding Protein 6 (Amisyn) (STXBP6) (N-Term) antibodySTXBP6 适用: 人, 小鼠, 大鼠, Cow, 马, 兔, 豚鼠, 斑马鱼, 猴, Pig, Bat, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin Binding Protein 6 (Amisyn) (STXBP6) (AA 71-97) antibodySTXBP6 适用: 人 WB 宿主: 兔 Polyclonal RB38006 unconjugated
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应用备注
- Optimal dilution of the STXBP6 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the STXBP6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- STXBP6 (Syntaxin Binding Protein 6 (Amisyn) (STXBP6))
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别名
- STXBP6
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背景
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STXBP6 antibody detects Syntaxin-binding protein 6, also known as Amisyn, a vesicle trafficking protein that regulates membrane fusion and neurotransmitter release. STXBP6 interacts with syntaxin family members and SNARE complexes, modulating vesicular exocytosis and endocytosis. The STXBP6 antibody is widely used in neurobiology and cell trafficking research to study synaptic regulation, vesicle dynamics, and membrane fusion events.
STXBP6 is encoded by the STXBP6 gene located on human chromosome 14q23.2. The protein is approximately 246 amino acids long and contains coiled-coil domains that facilitate interaction with syntaxins such as STX1A and STX3. STXBP6 localizes to the cytoplasm and plasma membrane, where it competes with other SNARE regulators to fine-tune exocytic activity.
The STXBP6 antibody detects a 28 kilodalton band by western blot and shows cytoplasmic and perinuclear puncta consistent with vesicle-associated localization. In neurons, STXBP6 modulates neurotransmitter release by inhibiting SNARE complex assembly under resting conditions and promoting controlled vesicle fusion upon stimulation. Beyond the nervous system, STXBP6 regulates exocytosis in endocrine and epithelial cells, influencing hormone and transporter release.
Loss or dysregulation of STXBP6 affects vesicle cycling, leading to synaptic transmission defects and altered cellular signaling. In cancer cells, altered STXBP6 expression influences migration and invasion through effects on membrane recycling and adhesion molecule trafficking. It also plays roles in insulin granule exocytosis and endosomal trafficking in non-neuronal tissues.
As a modulator of vesicle docking and fusion, STXBP6 serves as a versatile model for understanding SNARE-mediated transport and signal propagation. NSJ Bioreagents provides a validated STXBP6 antibody optimized for its applications, supporting research into synaptic physiology, secretion, and membrane dynamics. -
UniProt
- Q8NFX7
抗原
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