Ube2t 抗体 (AA 9-145)
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北京 101111
Quick Overview for Ube2t 抗体 (AA 9-145) (ABIN7877065)
抗原
See all Ube2t 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 9-145
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原理
- UBE2T Antibody / Ubiquitin-conjugating enzyme E2 T / HSPC150
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human UBE2T recombinant protein (Position: R9-Q145) was used as the immunogen for the UBE2T antibody.
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亚型
- IgG
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anti-Ubiquitin-Conjugating Enzyme E2T (Ube2t) (AA 1-197) antibody
Ube2t 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1E12-4A3 unconjugated
anti-Ubiquitin-Conjugating Enzyme E2T (Ube2t) antibodyKD Validated Ube2t 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB2350 unconjugated Recombinant Antibody
anti-Ubiquitin-Conjugating Enzyme E2T (Ube2t) (AA 1-197) antibodyUbe2t 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2A12-4F11 unconjugated
anti-Ubiquitin-Conjugating Enzyme E2T (Ube2t) (C-Term) antibodyUbe2t 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2T (Ube2t) (AA 1-197) antibodyUbe2t 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2T (Ube2t) antibodyKD Validated Ube2t 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2T (Ube2t) (C-Term) antibodyVerified Ube2t 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2T (Ube2t) (Internal Region) antibodyUbe2t 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2T (Ube2t) (N-Term) antibodyUbe2t 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2T (Ube2t) (Internal Region) antibodyUbe2t 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the UBE2T antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the UBE2T antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Ube2t (Ubiquitin-Conjugating Enzyme E2T (Ube2t))
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别名
- UBE2T
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背景
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UBE2T antibody detects Ubiquitin-conjugating enzyme E2 T, encoded by the UBE2T gene. Ubiquitin-conjugating enzyme E2 T is a member of the E2 family of enzymes that catalyze the transfer of ubiquitin to target proteins, particularly in the context of the Fanconi anemia DNA repair pathway. UBE2T antibody provides researchers with a critical reagent for studying ubiquitin signaling, DNA repair, and cancer.
Ubiquitin-conjugating enzyme E2 T functions as the cognate E2 for FANCL, the E3 ligase of the Fanconi anemia core complex. Research using UBE2T antibody has shown that it is required for monoubiquitination of FANCD2 and FANCI, a critical step in the repair of DNA interstrand crosslinks. This activity ensures faithful DNA replication and genome stability.
Studies with UBE2T antibody have revealed that loss of UBE2T function causes Fanconi anemia, a rare genetic disorder characterized by bone marrow failure, congenital abnormalities, and cancer predisposition. Patient mutations in UBE2T impair its ubiquitin conjugating activity, preventing activation of FANCD2 and disrupting DNA repair. These findings emphasize the clinical importance of UBE2T in genome maintenance.
Beyond Fanconi anemia, dysregulation of Ubiquitin-conjugating enzyme E2 T has been associated with cancer progression. Research using UBE2T antibody has shown that overexpression promotes proliferation, survival, and resistance to DNA-damaging therapies in breast, lung, and liver cancers. This suggests potential as both a biomarker and therapeutic target.
UBE2T antibody is widely applied in western blotting, immunohistochemistry, and functional repair assays. Western blotting detects monoubiquitination of FANCD2, immunohistochemistry demonstrates tumor-associated expression, and repair assays confirm participation in crosslink repair. These applications make UBE2T antibody indispensable in DNA repair and cancer biology.
By providing validated UBE2T antibody reagents, NSJ Bioreagents supports studies into ubiquitination, DNA repair, and disease. Detection of Ubiquitin-conjugating enzyme E2 T provides researchers with insight into how ubiquitin pathways regulate genome stability and cancer progression. -
UniProt
- Q9NPD8
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途径
- Chromatin Binding
抗原
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