MBNL1 抗体 (AA 89-388)
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Quick Overview for MBNL1 抗体 (AA 89-388) (ABIN7877057)
抗原
See all MBNL1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 89-388
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原理
- Muscleblind-like 1 Antibody / MBNL1
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纯化方法
- Affinity purified
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免疫原
- Recombinant human protein (amino acids Q89-M388) was used as the immunogen for the Muscleblind-like 1 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Muscleblind-like 1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Muscleblind-like 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MBNL1 (Muscleblind-like Protein 1 (MBNL1))
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别名
- Muscleblind-like 1
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背景
- Muscleblind-like (Drosophila), also known as MBNL1, is a protein that in humans is encoded by the MBNL1 gene. It is mapped to 3q25.1-q25.2. This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities.
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UniProt
- Q9NR56
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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