PFN2 抗体 (AA 87-139)
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Quick Overview for PFN2 抗体 (AA 87-139) (ABIN7877014)
抗原
See all PFN2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 87-139
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原理
- Zebrafish Pfn2 Antibody / Profilin 2 / Isoforms a & b
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纯化方法
- Antigen affinity chromatography
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免疫原
- An E.coli-derived zebrafish Pfn2a/b recombinant protein (amino acids I87-F139) was used as the immunogen for the Zebrafish Pfn2 antibody. This antibody will detect the a and b isoforms.
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亚型
- Ig Fraction
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应用备注
- Optimal dilution of the Zebrafish Pfn2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Pfn2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PFN2 (Profilin 2 (PFN2))
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别名
- Pfn2
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背景
- Profilin-2, also called PFN2, is a protein that in humans is encoded by the PFN2 gene. The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. This gene is mapped to 3q25.1. It is though to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. It binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
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UniProt
- Q6AZA1
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途径
- Regulation of Actin Filament Polymerization, Synaptic Vesicle Exocytosis
抗原
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