GSG2 抗体 (AA 86-798)
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Quick Overview for GSG2 抗体 (AA 86-798) (ABIN7877002)
抗原
See all GSG2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 86-798
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原理
- HASPIN Antibody / Serine/threonine-protein kinase haspin
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human GSG2/HASPIN recombinant protein (Position: R86-K798) was used as the immunogen for the HASPIN antibody.
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亚型
- IgG
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anti-Germ Cell Associated 2 (Haspin) (GSG2) (AA 323-352) antibody
GSG2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB3404 unconjugated
anti-Germ Cell Associated 2 (Haspin) (GSG2) antibodyGSG2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Germ Cell Associated 2 (Haspin) (GSG2) (AA 1-798) antibodyGSG2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Germ Cell Associated 2 (Haspin) (GSG2) (N-Term) antibodyGSG2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Germ Cell Associated 2 (Haspin) (GSG2) (AA 220-269) antibodyGSG2 适用: 人, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Germ Cell Associated 2 (Haspin) (GSG2) (AA 306-355) antibodyGSG2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Germ Cell Associated 2 (Haspin) (GSG2) (AA 300-350) antibodyGSG2 适用: 人 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Germ Cell Associated 2 (Haspin) (GSG2) antibodyGSG2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the HASPIN antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the HASPIN antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GSG2 (Germ Cell Associated 2 (Haspin) (GSG2))
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别名
- HASPIN
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背景
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The HASPIN antibody targets Serine/threonine-protein kinase haspin, a cell cycle-regulated kinase encoded by the GSG2 gene. Haspin is best known for phosphorylating histone H3 at threonine 3 (H3T3ph), a key mitotic modification that recruits the chromosomal passenger complex (CPC) to centromeres and ensures proper chromosome alignment during mitosis. The HASPIN antibody provides a critical reagent for investigating chromatin dynamics, mitotic regulation, and cell division fidelity.
Serine/threonine-protein kinase haspin is an atypical protein kinase with unique structural features distinguishing it from conventional kinase families. It remains active during mitosis and localizes to chromatin, where it marks centromeric regions to coordinate kinetochore function. The HASPIN antibody allows visualization of its distribution within dividing cells and quantification of total or active forms. This enables assessment of how Haspin integrates chromatin modification with spindle checkpoint signaling to maintain genomic stability.
Phosphorylation of histone H3 by Haspin serves as a molecular signal that recruits the Aurora B-containing CPC complex, which is essential for correcting improper microtubule-kinetochore attachments. Loss of Haspin activity disrupts chromosome segregation and leads to aneuploidy. The HASPIN antibody has therefore become a standard reagent for cell cycle and chromosome biology research, particularly in studies of mitotic kinase cascades and epigenetic checkpoint control.
In addition to its role in mitosis, Serine/threonine-protein kinase haspin has been implicated in spermatogenesis and embryonic development. Its expression in germ cells suggests functions in chromatin condensation and meiotic progression. The HASPIN antibody supports examination of these developmental contexts, providing insights into how histone phosphorylation contributes to chromatin organization beyond mitosis.
Given the importance of Haspin in maintaining genomic stability, it has emerged as a potential target for anticancer therapy. Inhibitors that block its kinase activity sensitize tumor cells to mitotic stress and disrupt proliferation. Researchers use the HASPIN antibody to evaluate target engagement and monitor cellular responses to Haspin inhibition. NSJ Bioreagents provides this antibody for reproducible performance across western blot, immunofluorescence, and immunohistochemistry assays. By enabling accurate detection of Serine/threonine-protein kinase haspin, this reagent supports the exploration of chromatin regulation, cell cycle control, and therapeutic targeting of mitotic kinases. -
UniProt
- Q8TF76
抗原
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