SNX16 抗体 (AA 84-344)
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Quick Overview for SNX16 抗体 (AA 84-344) (ABIN7876956)
抗原
See all SNX16 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 84-344
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原理
- SNX16 Antibody / Sorting nexin-16
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SNX16 recombinant protein (Position: I84-D344) was used as the immunogen for the SNX16 antibody.
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亚型
- IgG
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anti-Sorting Nexin 16 (SNX16) (N-Term) antibody
Verified SNX16 适用: 人 ELISA, WB, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Sorting Nexin 16 (SNX16) (AA 1-344) antibodySNX16 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1E9 unconjugated
anti-Sorting Nexin 16 (SNX16) (AA 1-342) antibodySNX16 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 16 (SNX16) (AA 250-300) antibodySNX16 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SNX16 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SNX16 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SNX16 (Sorting Nexin 16 (SNX16))
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别名
- SNX16
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背景
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SNX16 antibody detects Sorting nexin-16, a phosphoinositide-binding protein that regulates endosomal trafficking, membrane remodeling, and receptor recycling. SNX16 belongs to the sorting nexin family, which is characterized by the presence of a phox homology (PX) domain that interacts with phosphatidylinositol 3-phosphate-enriched membranes. The SNX16 antibody is widely used in cell biology and neurobiology research to investigate endosome organization and cargo transport.
SNX16 is encoded by the SNX16 gene located on human chromosome 8p21.3. The protein is approximately 62 kilodaltons and localizes primarily to early endosomes. It participates in the formation of tubular endosomal structures that mediate receptor sorting between degradation and recycling pathways. SNX16 functions independently of the retromer complex and instead promotes membrane tubulation through its coiled-coil domain. It regulates trafficking of receptors such as EGFR and TrkB, influencing growth factor signaling and neuronal development.
The SNX16 antibody typically identifies a 40-50 kilodalton protein by western blot and demonstrates punctate cytoplasmic staining characteristic of endosomal localization. Functional studies show that depletion of SNX16 disrupts endosomal tubulation, alters cargo recycling, and can impair signaling pathways dependent on receptor localization. Overexpression of SNX16 enhances endosomal membrane curvature and promotes receptor clustering, demonstrating its mechanochemical role in shaping endosomes.
In neurons, SNX16 contributes to dendritic spine maintenance and receptor turnover, impacting synaptic plasticity. It may also participate in autophagy regulation through endosome-lysosome fusion. Aberrant SNX16 expression has been linked to neurodegenerative disorders and cancer, where altered trafficking pathways contribute to signaling dysregulation. NSJ Bioreagents offers a validated SNX16 antibody, enabling researchers to explore endosomal dynamics, cargo sorting, and signaling modulation. -
UniProt
- P57768
抗原
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