TRIP6 抗体 (AA 8-476)
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Quick Overview for TRIP6 抗体 (AA 8-476) (ABIN7876835)
抗原
See all TRIP6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 8-476
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原理
- TRIP6 Antibody / Thyroid receptor-interacting protein 6
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human TRIP6 recombinant protein (Position: P8-C476) was used as the immunogen for the TRIP6 antibody.
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亚型
- IgG
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anti-Thyroid Hormone Receptor Interactor 6 (TRIP6) (AA 51-148) antibody
TRIP6 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4B7 unconjugated
anti-Thyroid Hormone Receptor Interactor 6 (TRIP6) (AA 107-291) antibodyTRIP6 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 6H4 unconjugated
anti-Thyroid Hormone Receptor Interactor 6 (TRIP6) (AA 1-100) antibodyTRIP6 适用: 人 WB, ELISA, IP, IF 宿主: 小鼠 Monoclonal 3D12 unconjugated
anti-Thyroid Hormone Receptor Interactor 6 (TRIP6) (AA 1-100) antibodyTRIP6 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Thyroid Hormone Receptor Interactor 6 (TRIP6) (AA 51-148) antibodyTRIP6 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Thyroid Hormone Receptor Interactor 6 (TRIP6) (AA 1-476) antibodyTRIP6 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Receptor Interactor 6 (TRIP6) (AA 1-476) antibodyTRIP6 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Thyroid Hormone Receptor Interactor 6 (TRIP6) antibodyTRIP6 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Receptor Interactor 6 (TRIP6) (Internal Region) antibodyVerified TRIP6 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Thyroid Hormone Receptor Interactor 6 (TRIP6) (AA 160-209) antibodyTRIP6 适用: 人, 小鼠, 大鼠, 马, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the TRIP6 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TRIP6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TRIP6 (Thyroid Hormone Receptor Interactor 6 (TRIP6))
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别名
- TRIP6
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背景
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TRIP6 antibody detects Thyroid receptor-interacting protein 6, a LIM domain-containing adaptor protein that links cell adhesion and cytoskeletal structures to signal transduction and transcriptional regulation. TRIP6 is part of the zyxin family of focal adhesion proteins and regulates cell motility, survival, and mechanical signaling. The TRIP6 antibody is widely used in cell signaling, cytoskeletal, and cancer biology to study focal adhesion dynamics and transcriptional control.
TRIP6 is encoded by the TRIP6 gene located on human chromosome 7q22.1. The protein is approximately 476 amino acids long and contains three LIM domains that mediate interactions with actin-associated proteins, kinases, and transcriptional regulators. TRIP6 localizes to focal adhesions, the cytoplasm, and the nucleus, reflecting its multifunctional role in signaling and structural regulation.
The TRIP6 antibody detects a 50 kilodalton band by western blot and shows strong focal adhesion staining under immunofluorescence. TRIP6 interacts with proteins such as paxillin, LPP, and integrin-linked kinase to regulate actin remodeling and cell migration. It also functions as a coactivator of transcription factors, including NF-kappaB and AP-1, linking mechanical and inflammatory signaling pathways.
In cancer, TRIP6 is frequently overexpressed and contributes to tumor cell migration, invasion, and survival. It mediates integrin and growth factor signaling, promoting metastasis through focal adhesion turnover and epithelial-to-mesenchymal transition. Conversely, in certain cell types, TRIP6 may act as a negative regulator of apoptosis and inflammation, demonstrating context-dependent roles.
As a versatile adaptor integrating cytoskeletal and transcriptional functions, TRIP6 is an important regulator of cellular mechanics and gene expression. NSJ Bioreagents provides a validated TRIP6 antibody optimized for its applications, supporting research into cell migration, mechanotransduction, and cancer progression. -
UniProt
- Q15654
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途径
- Cell-Cell Junction Organization
抗原
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