Lrig1 抗体 (AA 79-906)
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北京 101111
Quick Overview for Lrig1 抗体 (AA 79-906) (ABIN7876806)
抗原
See all Lrig1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 79-906
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原理
- LRIG1 Antibody / Leucine-rich repeats and immunoglobulin-like domains protein 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human LRIG1 recombinant protein (Position: K79-E906) was used as the immunogen for the LRIG1 antibody.
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亚型
- IgG
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anti-Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) (AA 1001-1093) antibody
Lrig1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) (AA 801-829), (C-Term) antibodyLrig1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB40253 unconjugated
anti-Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) (AA 35-220) antibodyLrig1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) (AA 1043-1093) antibodyLrig1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) (AA 35-220) antibodyLrig1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) (AA 739-995) antibodyLrig1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1) (AA 801-829) antibodyLrig1 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the LRIG1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the LRIG1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Lrig1 (Leucine-Rich Repeats and Immunoglobulin-Like Domains 1 (Lrig1))
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别名
- LRIG1
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背景
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LRIG1 antibody detects Leucine-rich repeats and immunoglobulin-like domains protein 1, a transmembrane protein that regulates growth factor receptor signaling and functions as a tumor suppressor. Encoded by the LRIG1 gene on chromosome 3p14.1, this protein contains multiple extracellular leucine-rich repeats and three immunoglobulin-like domains that enable binding to receptor tyrosine kinases, including members of the epidermal growth factor receptor (EGFR) family. LRIG1 promotes receptor ubiquitination and degradation, attenuating signaling that drives proliferation and differentiation.
LRIG1 localizes primarily to the plasma membrane but can also be detected in intracellular vesicles and the nucleus. It negatively regulates EGFR, ERBB2, and ERBB3 signaling by recruiting E3 ubiquitin ligases such as CBL to target receptors for degradation. In addition to receptor regulation, LRIG1 functions as a stem cell marker in epithelial tissues, maintaining quiescence and tissue renewal capacity. In the intestine and skin, LRIG1 marks long-lived stem cells essential for tissue homeostasis.
The LRIG1 antibody is widely used in cancer biology, stem cell, and developmental research to study growth factor receptor regulation, cell differentiation, and tumor suppression. Western blot analysis identifies a 120-150 kilodalton band corresponding to LRIG1, while immunohistochemistry reveals membrane and cytoplasmic staining in epithelial and neural tissues. This antibody supports investigations into receptor turnover, oncogenic signaling, and epithelial regeneration.
Loss or downregulation of LRIG1 is associated with tumor progression in gliomas, breast, and colorectal cancers due to hyperactivation of growth factor signaling. Conversely, overexpression suppresses tumor growth by dampening EGFR pathway activity. The LRIG1 antibody provides a reliable tool for studying receptor regulation, epithelial biology, and cancer suppression. NSJ Bioreagents offers this antibody validated for its applications, ensuring consistent detection in growth signaling research. -
UniProt
- Q96JA1
抗原
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