TRIM2 抗体 (AA 78-398)
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Quick Overview for TRIM2 抗体 (AA 78-398) (ABIN7876784)
抗原
See all TRIM2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 78-398
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原理
- TRIM2 Antibody / Tripartite motif-containing protein 2
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human TRIM2 recombinant protein (Position: Q78-E398) was used as the immunogen for the TRIM2 antibody.
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亚型
- IgG
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anti-Tripartite Motif Containing 2 (TRIM2) (AA 1-100), (AA 1500-1600) antibody
TRIM2 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 2B10 unconjugated
anti-Tripartite Motif Containing 2 (TRIM2) (C-Term) antibodyVerified TRIM2 适用: 人, 大鼠 WB, ELISA, FACS, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Tripartite Motif Containing 2 (TRIM2) (AA 1-100), (AA 645-744) antibodyTRIM2 适用: 人, 大鼠 WB, FACS 宿主: 小鼠 Monoclonal 4E5 unconjugated
anti-Tripartite Motif Containing 2 (TRIM2) (AA 1-100), (AA 645-744) antibodyTRIM2 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 2B2 unconjugated
anti-Tripartite Motif Containing 2 (TRIM2) (AA 233-247) antibodyVerified TRIM2 适用: 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
- Optimal dilution of the TRIM2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TRIM2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TRIM2 (Tripartite Motif Containing 2 (TRIM2))
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别名
- TRIM2
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背景
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TRIM2 antibody detects Tripartite motif-containing protein 2, an E3 ubiquitin ligase that regulates neuronal cytoskeleton organization and axonal stability. TRIM2 belongs to the TRIM family of RING finger E3 ligases and mediates ubiquitination of neurofilament proteins and signaling regulators. The TRIM2 antibody is widely used in neuroscience, developmental, and cell biology research to study axon maintenance, neurodegeneration, and ubiquitin-mediated proteostasis.
TRIM2 is encoded by the TRIM2 gene located on human chromosome 4q31.3. The protein is approximately 744 amino acids long and contains a RING finger domain, two B-boxes, a coiled-coil region, and a C-terminal filamin-binding NHL repeat domain. TRIM2 localizes to axons, growth cones, and perinuclear regions, reflecting its role in neuronal trafficking and cytoskeletal regulation.
The TRIM2 antibody detects a 90 kilodalton band by western blot and reveals filamentous cytoplasmic staining under immunofluorescence microscopy. TRIM2 ubiquitinates neurofilament light chain (NEFL) to control filament organization and turnover, maintaining axonal integrity and preventing neurodegenerative aggregation. It also regulates apoptosis by targeting proapoptotic proteins for degradation and interacts with signaling pathways involved in neuronal survival.
Mutations in TRIM2 cause hereditary axonal neuropathy and neurodegenerative disease characterized by axon swelling and degeneration. Dysregulation of TRIM2 expression has also been linked to gliomas and other cancers, where altered ubiquitination affects cytoskeletal dynamics and invasion. In developing neurons, TRIM2 coordinates cytoskeletal remodeling during axon guidance and branching.
Because of its key role in ubiquitin-mediated regulation of the neuronal cytoskeleton, TRIM2 serves as an essential molecule for understanding axonal maintenance and neuroprotection. NSJ Bioreagents provides a validated TRIM2 antibody optimized for its applications, supporting studies of ubiquitination, neurodevelopment, and axon integrity. -
UniProt
- Q9C040
抗原
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