NAP1L3 抗体 (AA 77-506)
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Quick Overview for NAP1L3 抗体 (AA 77-506) (ABIN7876766)
抗原
See all NAP1L3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 77-506
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原理
- NAP1L3 Antibody / Nucleosome assembly protein 1 like 3
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human NAP1L3 recombinant protein (Position: K77-K506) was used as the immunogen for the NAP1L3 antibody.
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亚型
- IgG
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anti-Nucleosome Assembly Protein 1-Like 3 (NAP1L3) (AA 1-506) antibody
NAP1L3 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Nucleosome Assembly Protein 1-Like 3 (NAP1L3) (AA 1-506) antibodyNAP1L3 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Nucleosome Assembly Protein 1-Like 3 (NAP1L3) (AA 432-459), (C-Term) antibodyNAP1L3 适用: 人 WB 宿主: 兔 Polyclonal RB37499 unconjugated
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应用备注
- Optimal dilution of the NAP1L3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the NAP1L3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- NAP1L3 (Nucleosome Assembly Protein 1-Like 3 (NAP1L3))
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别名
- NAP1L3
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背景
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NAP1L3 antibody detects Nucleosome assembly protein 1 like 3, encoded by the NAP1L3 gene. Nucleosome assembly protein 1 like 3 is a histone chaperone that regulates nucleosome dynamics and chromatin organization. NAP1L3 antibody provides researchers with a specific reagent for studying chromatin remodeling, transcriptional regulation, and epigenetics.
Nucleosome assembly protein 1 like 3 belongs to the NAP family of proteins that shuttle histones between the cytoplasm and the nucleus. Research using NAP1L3 antibody has shown that it facilitates the deposition of histones H2A and H2B onto DNA, a process essential for nucleosome formation. This activity supports both DNA replication and transcription, where nucleosome remodeling is required.
Studies with NAP1L3 antibody have revealed that this protein not only mediates histone assembly but also prevents inappropriate histone-DNA interactions by acting as a histone storage factor. This regulation maintains chromatin accessibility and ensures that transcriptional programs proceed accurately. The ability of NAP1L3 to regulate histone exchange links it to transcriptional activation and repression pathways.
Dysregulation of NAP1L3 has been associated with cancer and developmental disorders. Research using NAP1L3 antibody has shown that altered expression disrupts chromatin balance, leading to misregulated gene expression. Overexpression has been observed in certain tumors, where enhanced histone assembly promotes cell proliferation. Conversely, reduced expression impairs differentiation, underscoring its importance in development.
NAP1L3 antibody is commonly used in western blotting, immunohistochemistry, and chromatin immunoprecipitation. Western blotting quantifies histone chaperone levels, immunohistochemistry identifies nuclear localization, and chromatin immunoprecipitation maps chromatin interactions. These methods make NAP1L3 antibody valuable for epigenetic and transcriptional studies.
By supplying validated NAP1L3 antibody reagents, NSJ Bioreagents supports studies into chromatin remodeling, transcriptional regulation, and disease. Detection of Nucleosome assembly protein 1 like 3 provides researchers with insight into how histone chaperones regulate gene expression and cellular development. -
UniProt
- Q99457
抗原
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