Fibrillarin 抗体 (AA 77-138)
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Quick Overview for Fibrillarin 抗体 (AA 77-138) (ABIN7876758)
抗原
See all Fibrillarin (FBL) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 77-138
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原理
- FBL Antibody / Fibrillarin
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids K77-N138) was used as the immunogen for the FBL antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the FBL antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the FBL antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Fibrillarin (FBL)
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别名
- FBL
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背景
- RRNA 2'-O-methyltransferase fibrillarin is an enzyme that in humans is encoded by the FBL gene. This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8 % of humans with the autoimmune disease scleroderma recognize fibrillarin.
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UniProt
- P22087
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途径
- Ribonucleoside Biosynthetic Process
抗原
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