MED12 抗体 (AA 752-1974)
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Quick Overview for MED12 抗体 (AA 752-1974) (ABIN7876734)
抗原
See all MED12 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 752-1974
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原理
- MED12 Antibody / Mediator complex subunit 12
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纯化方法
- Antigen affinity purified
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免疫原
- An E.coli-derived human recombinant protein (Q752-Q1974) was used as the immunogen for the MED12 antibody.
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亚型
- IgG
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anti-Mediator Complex Subunit 12 (MED12) (AA 2127-2177) antibody
MED12 适用: 人, 小鼠 IHC, WB, IP, ICC, FACS 宿主: 兔 Monoclonal BLR084G unconjugated Recombinant Antibody
anti-Mediator Complex Subunit 12 (MED12) (AA 1991-2025), (C-Term) antibodyMED12 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB52354 unconjugated
anti-Mediator Complex Subunit 12 (MED12) (C-Term) antibodyMED12 适用: 人, 小鼠 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Mediator Complex Subunit 12 (MED12) (AA 1829-1941) antibodyMED12 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Mediator Complex Subunit 12 (MED12) (AA 1742-2011) antibodyMED12 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mediator Complex Subunit 12 (MED12) antibodyMED12 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mediator Complex Subunit 12 (MED12) (C-Term) antibodyMED12 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Mediator Complex Subunit 12 (MED12) (AA 251-350) antibodyMED12 适用: 小鼠, 大鼠 ELISA, WB, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the MED12 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MED12 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MED12 (Mediator Complex Subunit 12 (MED12))
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别名
- MED12
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背景
- Mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae), also known as MED12, is a human gene found on the X chromosome. The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.
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UniProt
- Q93074
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Stem Cell Maintenance, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha, Tube Formation
抗原
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