NUP98 抗体 (AA 728-1787)
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北京 101111
Quick Overview for NUP98 抗体 (AA 728-1787) (ABIN7876646)
抗原
See all NUP98 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 728-1787
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原理
- NUP98 Antibody / Nucleoporin 98
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human NUP98 recombinant protein (Position: H728-I1787) was used as the immunogen for the NUP98 antibody.
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亚型
- IgG
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anti-Nucleoporin 98kDa (NUP98) (AA 1-466) antibody
NUP98 适用: 人, 小鼠, 大鼠, Saccharomyces cerevisiae, Schizosaccharomyces pombe WB, ELISA, IF, ICC, DB 宿主: 大鼠 Monoclonal 2H10 unconjugated
anti-Nucleoporin 98kDa (NUP98) (GLFG Motif), (N-Term) antibodyNUP98 适用: 人, 小鼠, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Tetrahymena WB, IF 宿主: 小鼠 Monoclonal 21A10 unconjugated
anti-Nucleoporin 98kDa (NUP98) (FGxxN Motif), (N-Term) antibodyNUP98 适用: 人, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Tetrahymena WB, IF 宿主: 小鼠 Monoclonal 13C2 unconjugated
anti-Nucleoporin 98kDa (NUP98) antibodyNUP98 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Monoclonal 2H4 unconjugated Recombinant Antibody
anti-Nucleoporin 98kDa (NUP98) (AA 965-1110) antibodyNUP98 适用: 人 WB, ELISA, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Nucleoporin 98kDa (NUP98) (AA 621-920) antibodyNUP98 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Nucleoporin 98kDa (NUP98) antibodyNUP98 适用: 人 WB, IP 宿主: 小鼠 Monoclonal unconjugated
anti-Nucleoporin 98kDa (NUP98) (AA 1-606) antibodyNUP98 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Nucleoporin 98kDa (NUP98) antibodyNUP98 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Nucleoporin 98kDa (NUP98) (AA 1-110) antibodyNUP98 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the NUP98 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the NUP98 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- NUP98 (Nucleoporin 98kDa (NUP98))
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别名
- NUP98
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背景
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NUP98 antibody detects Nuclear pore complex protein Nup98, a critical nucleoporin involved in nucleocytoplasmic transport, gene regulation, and mitotic progression. Encoded by the NUP98 gene on chromosome 11p15.4, this large modular protein forms part of the nuclear pore complex (NPC), which mediates bidirectional transport of macromolecules between the nucleus and cytoplasm. Nup98 functions not only as a structural component of the NPC but also as a dynamic regulator of gene expression and chromatin organization.
Nup98 contains FG (phenylalanine-glycine)-repeat domains that form flexible meshwork structures facilitating selective nucleocytoplasmic transport. The C-terminal region anchors to the NPC scaffold via interactions with other nucleoporins such as Nup96 and Nup88. Beyond its classical transport role, Nup98 shuttles between the nuclear envelope and nucleoplasm, where it binds transcriptional regulators, influencing developmental and immune response genes. It also participates in RNA export, mRNA surveillance, and mitotic spindle assembly.
The NUP98 antibody is widely used in cell biology, oncology, and molecular genetics research to study nuclear transport, chromatin organization, and cell cycle regulation. Western blot analysis identifies a 98 kilodalton band corresponding to Nup98, while immunofluorescence shows punctate staining at the nuclear envelope and within nucleoplasmic foci. This antibody supports studies examining NPC function, transcriptional regulation, and nuclear architecture integrity.
Translocations involving NUP98 are recurrent in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), producing oncogenic Nup98 fusion proteins such as NUP98-HOXA9 and NUP98-NSD1. These fusions retain the FG-repeat domain of Nup98 but acquire transcriptional activation capabilities from their fusion partners, leading to deregulated gene expression and leukemogenesis. The NUP98 antibody provides a reliable tool for studying such fusion proteins and their oncogenic mechanisms. NSJ Bioreagents validates this antibody for its applications, ensuring accurate detection for nuclear transport and cancer research. -
UniProt
- P52948
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途径
- Stem Cell Maintenance, Protein targeting to Nucleus, SARS-CoV-2 Protein Interactome
抗原
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