TRIM31 抗体 (AA 72-335)
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北京 101111
Quick Overview for TRIM31 抗体 (AA 72-335) (ABIN7876635)
抗原
See all TRIM31 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 72-335
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原理
- TRIM31 Antibody / Tripartite motif-containing protein 31
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human TRIM31 recombinant protein (Position: R72-E335) was used as the immunogen for the TRIM31 antibody.
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亚型
- IgG
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anti-Tripartite Motif Containing 31 (TRIM31) (AA 186-425) antibody
TRIM31 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 31 (TRIM31) (AA 1-100) antibodyTRIM31 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 2G11 unconjugated
anti-Tripartite Motif Containing 31 (TRIM31) (AA 117-166) antibodyTRIM31 适用: 人, Cow, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 31 (TRIM31) (Internal Region) antibodyTRIM31 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 31 (TRIM31) (AA 186-425) antibodyTRIM31 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 31 (TRIM31) (N-Term) antibodyTRIM31 适用: 人, 小鼠, 兔, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 31 (TRIM31) (AA 1-425) antibodyTRIM31 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Tripartite Motif Containing 31 (TRIM31) (C-Term) antibodyTRIM31 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 31 (TRIM31) (AA 288-337) antibodyTRIM31 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the TRIM31 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TRIM31 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TRIM31 (Tripartite Motif Containing 31 (TRIM31))
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别名
- TRIM31
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背景
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TRIM31 antibody detects Tripartite motif-containing protein 31, an E3 ubiquitin ligase involved in innate immune regulation, antiviral defense, and tumor suppression. TRIM31 belongs to the TRIM family, characterized by RING, B-box, and coiled-coil domains that mediate ubiquitination and protein complex assembly. The TRIM31 antibody is widely used in immunology, virology, and oncology to study ubiquitin-mediated signaling and inflammation control.
TRIM31 is encoded by the TRIM31 gene on human chromosome 6p22.1. The protein is approximately 478 amino acids long and localizes to the cytoplasm and mitochondria. TRIM31 acts as an E3 ubiquitin ligase that targets specific signaling intermediates for degradation or activation, thus modulating innate immune pathways such as RIG-I and MAVS. Through ubiquitination, TRIM31 promotes antiviral signaling by facilitating MAVS aggregation and interferon production.
The TRIM31 antibody detects a 55 kilodalton protein by western blot and demonstrates cytoplasmic punctate staining. In addition to its role in antiviral defense, TRIM31 regulates inflammasome activation and apoptosis. It ubiquitinates NLRP3 and p53, thereby controlling inflammatory and apoptotic responses. Dysregulation of TRIM31 leads to chronic inflammation and has been implicated in autoimmune diseases and metabolic disorders.
In cancer, TRIM31 can function as both an oncogene and tumor suppressor depending on cellular context. Overexpression of TRIM31 promotes proliferation and invasion in gastric and pancreatic cancers, whereas loss of TRIM31 contributes to tumorigenesis through impaired apoptosis regulation. TRIM31 expression is also linked to mitochondrial quality control via regulation of mitophagy, emphasizing its multifaceted cellular functions.
As a key E3 ligase coordinating immune, inflammatory, and metabolic pathways, TRIM31 represents a versatile model for studying ubiquitin signaling networks. NSJ Bioreagents provides a validated TRIM31 antibody optimized for its applications, supporting research into antiviral defense, protein turnover, and cancer biology. -
UniProt
- Q9BZY9
抗原
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